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https://www.chemistryworld.com/news/oral-delivery-of-anticancer-drug/9124.article
The carrier also improves the oral pharmacokinetics and cell uptake, and sustains release of the drug. Tests on mice showed the efficacy of orally delivered asplatin using the new carrier is comparable to that of injected cisplatin and considerably better than that of other Pt(IV) prodrugs delivered orally without the PEGylated nanoparticles.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138023/
Multiple nanoemulsion system for an oral combinational delivery of oxaliplatin and 5-fluorouracil: preparation and in vivo evaluation. ... It is difficult to optimize oral delivery of a hydrophilic drug in the form of a self-nanoemulsifying system by w/o emulsion because phase separation of the external oil phase or fast precipitation of drug ...Author: Rudra Pangeni, Sang Won Choi, Ok-Cheol Jeon, Youngro Byun, Jin Woo Park
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721547/
Oral cancer is ranked the 16th most common form of cancer and accounted for 2% of all newly diagnosed cancer cases in 2018 . Up to 90% of oral malignancies are diagnosed as oral squamous cell carcinoma (OSCC) . Chemotherapy as an optional combination treatment for OSCC, has been shown to enhance the overall survival of patients with advanced ...Author: Xin-Hui Khoo, Ian C. Paterson, Bey-Hing Goh, Wai-Leng Lee
http://www.eurekaselect.com/140739/article
Keywords:Cisplatin, combination delivery, drug delivery, drug resistance, prodrug, tumor therapy. Abstract:Cisplatin is one of the leading chemotherapy drugs currently used in clinical settings. However, its serious side effects and its resistance developed by tumor cells hinder its usage.Author: Zhanguo Yue, Zhiqiang Cao
https://www.nature.com/articles/s41598-019-45964-9
Jul 02, 2019 · Oral administration of caffeine exacerbates cisplatin-induced hearing loss in rats. Immunohistochemical studies from our laboratory have clearly shown the …Author: Sandeep Sheth, Kelly Sheehan, Asmita Dhukhwa, Raheem F. H. Al Aameri, Chaitanya Mamillapalli, Debash...
https://soundpharma.com/wp-content/uploads/2017/10/Lynch-2005b-Chemoprotection1.pdf
Combined oral delivery of ebselen and allopurinol reduces multiple cisplatin toxicities in rat breast and ovarian cancer models while enhancing anti-tumor activity Eric D. Lynch a, Rende Gu a, Carol Pierce a and Jonathan Kil a The chemoprotective effects of combined ebselen and allopurinol in breast (MTLn3) and ovarian (NuTu-19) cancer
https://www.sciencedirect.com/science/article/pii/S1773224716301095
There have been two studies reported concerning oral administration of CDDP, one study involving a CDDP-loaded solid dispersion in rats , and another involving oral or intravenous CDDP delivery in 32 human patients , which examined only the pharmacokinetics of CDDP. But no oral formulation of CDDP is commercially available.Author: Ryosuke Miyasaka, Keiichiro Kikukawa, Shuji Sakuma
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