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https://www.sciencedirect.com/science/article/pii/S0142961213011617
Finally, areas that are noteworthy in CD-based gene delivery will be highlighted for future research. Due to the application prospects of CDs, it is anticipated that CDs will continue to emerge as an important tool for vector development, and will play significant roles in facilitating non-viral gene delivery in the forthcoming decades.Author: Wing-Fu Lai
https://www.ingentaconnect.com/contentone/ben/pnt/2013/00000001/00000001/art00005
Cyclodextrins (CDs) are cyclic oligosaccharides derived from starch and are well characterised pharmaceutical excipients. They offer many advantages as potential non-viral vectors for gene and siRNA delivery, in particular the ease with which they can be chemically modified and their lack of toxicity.
http://www.eurekaselect.com/105618
Keywords:Click chemistry, cyclodextrins, genes, non-viral delivery, pre-clinical, siRNA. Abstract:Considerable research is focused on the development of non-viral vectors for gene and RNA interference therapies, with significant advancements in this field over the past number of years. Cationic lipids and polymers have been extensively ...Author: Aoife M. O'Mahony, Martin J. O'Neill, Bruno M.D.C. Godinho, Raphael Darcy, John F. Cryan, Caitriona ...
https://www.researchgate.net/publication/257533493_Cyclodextrins_in_non-viral_gene_delivery
While much of the initial success of gene delivery relied on viral vectors, non-viral vectors are emerging as promising gene delivery systems for efficacious treatment with decreased toxicity ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689829/
Optimising non-viral vectors for neuronal siRNA delivery presents a significant challenge. Here, we investigate a co-formulation, consisting of two amphiphilic cyclodextrins (CDs), one cationic and the other PEGylated, which were blended together for siRNA delivery to a neuronal cell culture model.Author: Aoife M. O'Mahony, Julien R. Ogier, Raphael Darcy, John F. Cryan, Caitríona M. O'Driscoll
https://pubs.acs.org/doi/full/10.1021/cn3000372
RNA interference (RNAi) holds great promise as a strategy to further our understanding of gene function in the central nervous system (CNS) and as a therapeutic approach for neurological and neurodegenerative diseases. However, the potential for its use is hampered by the lack of siRNA delivery vectors which are both safe and highly efficient.Author: Aoife M. O'Mahony, Bruno M. D. C. Godinho, Julien R. Ogier, Marc Devocelle, Raphael Darcy, John F. C...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3474283/
Oct 17, 2012 · However, the potential for its use is hampered by the lack of siRNA delivery vectors which are both safe and highly efficient. Cyclodextrins have been shown to be efficient and low toxicity gene delivery vectors in various cell types in vitro. However, to date, they have not been exploited for delivery of oligonucleotides to neurons.Author: Aoife M. O'Mahony, Bruno M. D. C. Godinho, Julien R. Ogier, Marc Devocelle, Raphael Darcy, John F. C...
https://www.sciencedirect.com/science/article/pii/S092809871730653X
Mar 01, 2018 · Cyclodextrin-siRNA conjugates as versatile gene silencing agents. ... C.M. O'DriscollCharacterisation of cationic amphiphilic cyclodextrins for neuronal delivery of siRNA: effect of reversing primary and secondary face ... B. Godinho, R. Darcy, F. Cryan, C. O'DriscollCyclodextrins for non-viral gene and siRNA delivery. Pharm. Nanotechnol., 1 ...Author: Meenakshi Malhotra, Meenakshi Malhotra, Matt Gooding, James C. Evans, James C. Evans, Daniel O'Drisc...
https://link.springer.com/article/10.1007/s13346-020-00724-5
Feb 19, 2020 · Gene therapy is a powerful tool against genetic disorders and cancer, targeting the source of the disease rather than just treating the symptoms. While much of the initial success of gene delivery relied on viral vectors, non-viral vectors are emerging as promising gene delivery systems for efficacious treatment with decreased toxicity concerns.Author: Rebecca M. Haley, Riccardo Gottardi, Riccardo Gottardi, Robert Langer, Michael J. Mitchell
https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-018-1402-1
Feb 15, 2018 · Critical tissue defects frequently result from trauma, burns, chronic wounds and/or surgery. The ideal treatment for such tissue loss is autografting, but donor sites are often limited. Tissue engineering (TE) is an inspiring alternative for tissue repair and regeneration (TRR). One of the current state-of-the-art methods for TRR is gene therapy. Non-viral gene delivery systems (nVGDS) have ...Author: Pan Wu, Haojiao Chen, Ronghua Jin, Tingting Weng, Jon Kee Ho, Chuangang You, Liping Zhang, Xingang W...
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