Current Options For Drug Delivery To The Spinal Cord

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Current options for drug delivery to the spinal cord.

    https://www.ncbi.nlm.nih.gov/pubmed/23289716
    Current options for drug delivery to the spinal cord. Rossi F(1), Perale G, Papa S, Forloni G, Veglianese P. Author information: (1)Dipartimento di Neuroscienze, Istituto di Ricerche Farmacologiche Mario Negri, via La Masa 19, 20156 Milano, Italy.Author: Filippo Rossi, Giuseppe Perale, Simonetta Papa, Gianluigi Forloni, Pietro Veglianese

Current options for drug delivery to the spinal cord ...

    https://www.tandfonline.com/doi/abs/10.1517/17425247.2013.751372
    Mar 10, 2016 · Introduction: Spinal cord disorders (SCDs) are among the most devastating neurological diseases, due to their acute and long-term health consequences, the reduced quality of life and the high economic impact on society. Here, drug administration is severely limited by the blood–spinal cord barrier (BSCB) that impedes to reach the cord from the bloodstream.Author: Filippo Rossi, Giuseppe Perale, Simonetta Papa, Gianluigi Forloni, Pietro Veglianese

Current options for drug delivery to the spinal cord ...

    https://moh-it.pure.elsevier.com/en/publications/current-options-for-drug-delivery-to-the-spinal-cord
    title = "Current options for drug delivery to the spinal cord", abstract = "Introduction: Spinal cord disorders (SCDs) are among the most devastating neurological diseases, due to their acute and long-term health consequences, the reduced quality of life and the high economic impact on society.Author: Filippo Rossi, Giuseppe Perale, Simonetta Papa, Gianluigi Forloni, Pietro Veglianese

Current Options for Cell Therapy in Spinal Cord Injury ...

    https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(17)30123-5
    Sep 01, 2017 · Spinal cord injury (SCI) is a complex pathology that evolves after primary acute mechanical injury, causing further damage to the spinal cord tissue that exacerbates clinical outcomes. Based on encouraging results from preclinical experiments, some cell treatments being translated into clinical practice demonstrate promising and effective improvement in sensory/motor function. …Author: Irma Vismara, Simonetta Papa, Filippo Rossi, Gianluigi Forloni, Pietro Veglianese

Mesenchymal Stem Cells for Spinal Cord Injury: Current ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600381/
    May 31, 2019 · 1. Introduction. Spinal cord injury (SCI) constitutes an inestimable public health issue, with an incidence of 40–80 per million people per year [].Generally, young adults are involved, where the burden of permanent neurological damage is unbearable for patients, for their caregivers, and for …Author: Fabio Cofano, Marina Boido, Matteo Monticelli, Francesco Zenga, Alessandro Ducati, Alessandro Vercel...

Current Options for Cell Therapy in Spinal Cord Injury

    https://www.cell.com/trends/molecular-medicine/pdf/S1471-4914(17)30123-5.pdf
    Current Options for Cell Therapy in Spinal Cord Injury Irma 1 Vismara,1,3 Simonetta Papa,1,3 Filippo Rossi,2 Gianluigi Forloni, and Pietro Veglianese1,* Spinal cord injury (SCI) is a complex pathology that evolves after primary acute mechanical injury, causing further damage to the spinal cord tissue that exac-erbates clinical outcomes.

Intrathecal drug delivery in the era of nanomedicine ...

    https://www.sciencedirect.com/science/article/pii/S0169409X20300120
    Administration of substances directly into the cerebrospinal fluid (CSF) that surrounds the brain and spinal cord is one approach that can circumvent the blood-brain barrier to enable drug delivery to the central nervous system (CNS).Author: M.J. Fowler, J.D. Cotter, B.E. Knight, E.M. Sevick-Muraca, D.I. Sandberg, D.I. Sandberg, R.W. Sirian...

Spinal drug delivery SpringerLink

    https://link.springer.com/article/10.1007/s11916-001-0068-0
    Dec 01, 2001 · Clinicians currently base decisions regarding the use of intrathecal drug therapy for chronic pain on reports from uncontrolled and retrospective studies that fail to rely on standardized outcome measures. In this article, we summarize what is known about currently administered intrathecal therapies, including opioids, gamma-aminobutyric acid agonists, alpha-2 adrenoreceptor agonists, …Author: Theodore S. Grabow, David Derdzinski, Peter S. Staats

Current Options for Cell Therapy in Spinal Cord Injury ...

    https://www.sciencedirect.com/science/article/abs/pii/S1471491417301235
    Current Options for Cell Therapy in Spinal Cord Injury. ... and Schwann cells can contribute to replacing spinal cord architecture and functionality. ... This review provides an overview of single and combinatorial regenerative cell treatments as well as potential delivery options to treat SCI.Author: Irma Vismara, Simonetta Papa, Filippo Rossi, Gianluigi Forloni, Pietro Veglianese

Spinal Cord Injury: Hope Through Research National ...

    https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Hope-Through-Research/Spinal-Cord-Injury-Hope-Through-Research
    The drug riluzole, which slows the progression of the disease amyotrophic lateral sclerosis, has shown in animal models to improve motor function and reduce cell death loss caused by decreased blood flow following spinal cord injury. The experimental drug HP 184 blocks the entry of sodium into cells (which can impair nerve function) and may ...

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