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https://www.ncbi.nlm.nih.gov/pubmed/22201583
1. Curr Pharm Biotechnol. 2012 Jun;13(7):1279-91. Critical issues in delivery of RNAi therapeutics in vivo. Rivera S(1), Yuan F. Author information: (1)Department of Biomedical Engineering, Duke University, 136 Hudson Hall Durham, NC 27708, USA. [email protected] RNA interference (RNAi) is a fundamental mechanism of gene regulation and has been harnessed to produce a new class of ...Author: Stephanie Rivera, Fan Yuan
http://www.eurekaselect.com/openurl/content.php?genre=article&issn=1389-2010&volume=13&issue=7&spage=1279
Approaches to RNA delivery are divided into three categories in this review: biological, chemical, and physical. Advantages and disadvantages of each method are discussed. At present, effective delivery of RNAi therapeutics in vivo is still a challenge although significant advances have been made in this field.
https://www.ingentaconnect.com/content/ben/cpb/2012/00000013/00000007/art00016
RNA interference (RNAi) is a fundamental mechanism of gene regulation and has been harnessed to produce a new class of drugs for treatment of various diseases. A key issue in these applications is how to effectively deliver RNAi therapeutics into target cells. This review is …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978219/
Mar 30, 2007 · The method of delivery used in a number of in vivo studies, hydrodynamic intravenous injection, is not feasible for the treatment of human hepatitis. Delivery is a problem that must be confronted for any therapeutic application of RNAi.Author: Lars Aagaard, John J. Rossi
https://www.nature.com/articles/gt201141
Apr 07, 2011 · Despite successful demonstration of RNAi in vivo and initiation of clinical trials using RNAi-based therapeutics, safety and delivery of RNAi remain critical issues. 1, …Author: A Koornneef, R van Logtenstein, E Timmermans, L Pisas, B Blits, X Abad, P Fortes, H Petry, P Konstan...
https://www.researchgate.net/publication/234140538_in_vivo_delivery_aspects_of_miRNA_shRNA_and_siRNA
in vivo delivery aspects of miRNA, shRNA and siRNA. ... However, in vivo delivery of RNAi therapeutics is restricted because of charge density, molecular weight, and instability in the presence of ...
http://www.nature.com/articles/nchembio839
Dec 01, 2006 · RNAi therapeutics: a potential new class of pharmaceutical drugs ... and strategies for facilitating cellular delivery in vivo through conjugation, complexation and lipid-based approaches to ...Author: David Bumcrot, Muthiah Manoharan, Victor Koteliansky, Dinah W Y Sah
https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-017-0450-0
Jun 27, 2017 · In this review, we discuss the challenges for clinical translation of RNA-based therapeutics, with an emphasis on recent advances in delivery technologies, and present an overview of the applications of RNA-based drugs for modulation of gene/protein expression and genome editing that are currently being investigated both in the laboratory as ...Author: James C. Kaczmarek, Piotr S. Kowalski, Daniel G. Anderson
https://altogen.com/transfection-resource/rnai-therapeutics/
Altogen Biosystems provides in vivo transfection reagents, over 100 pre-optimized in vitro transfection kits for cell lines and primary cells, and electroporation delivery products. Transfection reagents are highly efficient for DNA and siRNA transfection in vivo and in vitro. Altogen CRO offers in vivo RNAi services, tumor xenograft models, toxicology testing, stable cell line generation, and ...
https://www.genengnews.com/uncategorized/rnai-therapeutics-to-the-liver-and-beyond/
Mar 14, 2018 · “RNAi, specifically the sd-rxRNA platform, is uniquely suited for ex vivo treatment of immune cells in the context of adoptive cell transfer and other cell therapies,” the company states ...
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