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https://www.mdpi.com/1422-0067/17/11/1892/htm
In general, the CPP-assisted drug delivery can be realized through three means: (1) via covalent conjugation of the drug molecule with a CPP; (2) encapsulation of the therapeutics into CPP-linked nano-carriers; and (3) by physical adsorption of the therapeutic agents with CPPs via …Author: Junxiao Ye, Junxiao Ye, Ergang Liu, Ergang Liu, Zhili Yu, Xing Pei, Sunhui Chen, Pengwei Zhang, Peng...
https://www.ncbi.nlm.nih.gov/pubmed/27854260
Nov 14, 2016 · However, non-specific CPP-mediated cell penetration into normal tissues can lead to widespread organ distribution of the payloads, thereby reducing the therapeutic efficacy of the drug and at the same time increasing the drug-induced toxic effects.Author: Junxiao Ye, Junxiao Ye, Ergang Liu, Ergang Liu, Zhili Yu, Xing Pei, Sunhui Chen, Pengwei Zhang, Peng...
https://www.sciencedirect.com/science/article/pii/S0005273606000058
Delivery of cargo attached to a CPP requires endosomal release, for which different methods have recently been proposed. Positively charged amino acids, hydrophobicity and/or amphipathicity are common to CPPs. Moreover, some CPPs can self-assemble. Herein is discussed the role of self assembly in the cellular uptake of CPPs.Author: Sílvia Pujals, Jimena Fernández-Carneado, Carmen López-Iglesias, Marcelo J. Kogan, Ernest Giralt
https://www.anaspec.com/products/productcategory.asp?id=158
56 rows · Peptides , Cell Permeable Peptides (CPP) , Drug Delivery Peptides; Efficient transfer of …
https://www.tandfonline.com/doi/abs/10.1080/17425247.2019.1665021
Introduction : Cell-penetrating peptides (CPP) offer versatile tools for the field of drug delivery and development of macromolecular therapeutics. These tools have matured into applications that allow the use of proteins, nucleic acid, peptides, imaging agents, and low molecular weight drugs …Author: Kaido Kurrikoff, Ülo Langel
https://www.manufacturingchemist.com/technical/article_page/CPPs_beating_drug_delivery_barriers/104817
Jan 26, 2015 · CPP-drug conjugates in clinical trials: Research and clinical studies on the transport and delivery of therapeutics into cellular targets using cell penetrating peptides has progressed well in recent years. In a transport feasibility study Tat was shown to be able to shuttle a N-(2-hydroxypropyl) methacrylamide (HPMA) copolymer and the doxorubicin into a human ovarian carcinoma cell line.
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