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http://www.vetmed.vt.edu/clinical-trials/canine-glioma/convection-enhanced-delivery.asp
Convection Enhanced Delivery (CED) is a therapeutic strategy that was developed to facilitate targeted delivery of pharmaceuticals to the brain. The CED procedure involves a minimally invasive surgical exposure of the brain, followed by placement of small diameter catheters directly into the brain tumor. Subsequently, infusion of therapeutics into the tumor occurs over several hours to saturate the …
https://braintumorcenter.ucsf.edu/treatment/experimental-diagnostics-therapies/convection-enhanced-delivery
Convection Enhanced Delivery Using standard chemotherapy on brain tumors is challenging, considering that many of these drugs (administered as a pill, or injected intravenously…
https://cancerres.aacrjournals.org/content/65/15/6858
Aug 01, 2005 · Convection-enhanced drug delivery (CED) is a novel approach to directly deliver drugs into brain tissue and brain tumors. It is based on delivering a continuous infusion of drugs via intracranial catheters, enabling convective distribution of high drug concentrations over large volumes of the target tissue while avoiding systemic toxicity.Author: Yael Mardor, Ofer Rahav, Yacov Zauberman, Zvi Lidar, Aharon Ocherashvilli, Dianne Daniels, Yiftach R...
https://surgicalneurologyint.com/surgicalint-articles/convection-enhanced-drug-delivery-for-gliomas/
Interstitial drug administration via convection-enhanced delivery (CED) is an alternative that potentially overcomes systemic toxicities and CNS delivery issues by directly bypassing the blood–brain barrier …
http://www.aetna.com/cpb/medical/data/700_799/0731.html
Convection-enhanced delivery (CED) is a method of directly administering drugs into the brain in order to enhance the distribution of drugs throughout the brain parehcyma. It involves the stereotactic placement through cranial burr holes of several catheters into brain parenchyma and the subsequent infusion of antineoplastic agents or other therapeutic agents via a microinfusion pump.
https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(18)30322-X/fulltext
Convection-enhanced delivery in the brainstem of children with diffuse intrinsic pontine glioma who have previously received radiation therapy seems to be a rational and safe therapeutic strategy.Author: Mark M Souweidane, Mark M Souweidane, Kim Kramer, Kim Kramer, Neeta Pandit-Taskar, Neeta Pandit-Task...
https://link.springer.com/article/10.1007/s13311-017-0520-4
Mar 15, 2017 · Convection-enhanced delivery (CED) is a promising technique that generates a pressure gradient at the tip of an infusion catheter to deliver therapeutics directly through the interstitial spaces of the central nervous system.Author: A. M. Mehta, A. M. Sonabend, J. N. Bruce
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657605/
Convection-enhanced delivery (CED) has been designed to overcome some of the difficulties so that pharmacological agents that would not normally cross the BBB can be used for treatment. Drugs are delivered through one to several catheters placed stereotactically directly within the tumor mass or around the tumor or the resection cavity.Author: Waldemar Debinski, Stephen B Tatter
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