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https://en.wikipedia.org/wiki/Acoustic_targeted_drug_delivery
Sonodynamic therapy is a proposed form of treatment using drugs that only become cytotoxic upon exposure to ultrasound. Since ultrasound can be focused into small tissue volumes within the body, this method provides a potential means of localizing treatment and reducing the risk of toxic side-effects elsewhere in the body.
https://en.wikipedia.org/wiki/DIPG
Convection-enhanced delivery: Chemotherapy is delivered to the tumour by a surgically implanted catheter under a pressure gradient to achieve more distribution than with diffusion alone. Limited experiments have been conducted with brain tumors, including one with a DIPG.
https://www.ncbi.nlm.nih.gov/pubmed/19831841
The brain is highly accessible for nutrients and oxygen, however delivery of drugs to malignant brain tumors is a very challenging task. Convection-enhanced delivery (CED) has been designed to overcome some of the difficulties so that pharmacological agents that would not normally cross the BBB can be used for treatment.Author: Waldemar Debinski, Stephen B Tatter
https://en.wikipedia.org/wiki/Convection
Convection is the heat transfer due to the bulk movement of molecules within fluids such as gases and liquids, including molten rock ().Convection includes sub-mechanisms of advection (directional bulk-flow transfer of heat), and diffusion (non-directional transfer of …
https://www.medscape.com/viewarticle/712531
Nov 06, 2019 · The brain is highly accessible for nutrients and oxygen, however delivery of drugs to malignant brain tumors is a very challenging task. Convection-enhanced delivery (CED) has …
https://link.springer.com/article/10.1007/s13311-017-0520-4
Mar 15, 2017 · Convection-enhanced delivery (CED) is a promising technique that generates a pressure gradient at the tip of an infusion catheter to deliver therapeutics directly through the interstitial spaces of the central nervous system. It addresses and offers solutions to many limitations of conventional techniques, allowing for delivery past the blood–brain barrier in a targeted and safe manner that ...Author: A. M. Mehta, A. M. Sonabend, J. N. Bruce
https://en.wikipedia.org/wiki/John_H._Sampson
This biography of a living person needs additional citations for verification, as its only attribution is to self-published sources; articles should not be based solely on such sources. Please help by adding reliable, independent sources.Contentious material about living people that is unsourced or poorly sourced must be removed immediately. (April 2015) (Learn how and when to remove this ...
https://www.medscape.com/viewarticle/712531_3
Sep 26, 2019 · Figure 1. Schema of several catheters tested for convection-enhanced delivery. Arrows symbolize the flow of infusate during convection-enhanced delivery.
https://www.smartpatients.com/trials/NCT02303678
Summary. This is a Phase I study to determine the maximum tolerated dose (MTD) and/or recommended phase II dose of D2C7-IT (D2C7 Immunotoxin) when delivered intratumorally by convection-enhanced delivery (CED) to recurrent World Health Organization (WHO) grade III and IV malignant glioma patients, and/or to determine what dose will be considered in a Phase II trial.
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0132266
We currently use Convection-Enhanced Delivery (CED) of the platinum-based drug, carboplatin as a novel treatment strategy for high grade glioblastoma in adults and children. Although initial results show promise, carboplatin is not specifically toxic to tumour cells and has been associated with neurotoxicity at high infused concentrations in pre-clinical studies. Our treatment strategy ...
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