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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC43312/
Mar 15, 1994 · Convection-enhanced delivery of macromolecules in the brain. R H Bobo , D W Laske , A Akbasak , P F Morrison , R L Dedrick , and E H Oldfield Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.
https://www.ncbi.nlm.nih.gov/pubmed/8134351
Mar 15, 1994 · Convection-enhanced delivery of macromolecules in the brain. Bobo RH(1), Laske DW, Akbasak A, Morrison PF, Dedrick RL, Oldfield EH. Author information: (1)Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of …Author: R H Bobo, D W Laske, A Akbasak, P F Morrison, R L Dedrick, E H Oldfield
https://www.pnas.org/content/91/6/2076
Mar 15, 1994 · For many compounds (neurotrophic factors, antibodies, growth factors, genetic vectors, enzymes) slow diffusion in the brain severely limits drug distribution and effect after direct drug administration into brain parenchyma. We investigated convection as a means to enhance the distribution of the large and small molecules 111In-labeled transferrin (111In-Tf; M(r), 80,000) and [14C]sucrose …Author: R H Bobo, D W Laske, A Akbasak, P F Morrison, R L Dedrick, E H Oldfield
https://www.pnas.org/content/pnas/91/6/2076.full.pdf
into brain is extremely limited for high molecular weight compounds (8). After direct administration into the brain, limited diffusion in the brain severely retards the rate of distribution ofsuchcompounds. Intratumoral chemotherapy for brain tumors has been administered by direct injection, intracavitary instillation,Author: R H Bobo, D W Laske, A Akbasak, P F Morrison, R L Dedrick, E H Oldfield
https://www.sciencedirect.com/science/article/pii/S0006899306031118
Retro-convection enhanced delivery to increase blood to brain transfer of macromolecules. ... F.C. Szoka Jr.Distribution in brain of liposomes after convection enhanced delivery; modulation by particle charge, particle diameter, and presence of steric coating.Author: Grace H. Huynh, Tomoko Ozawa, Dennis F. Deen, Tarik Tihan, Francis C. Szoka
http://www.eurekaselect.com/103404/article
Abstract: The blood brain barrier (BBB) poses a significant challenge for drug delivery of macromolecules into the brain. Convection-enhanced delivery (CED) circumvents the BBB through direct intracerebral infusion using a hydrostatic pressure gradient to transfer therapeutic compounds.Author: Ankit I. Mehta, Bryan D. Choi, Divya Ajay, Raghu Raghavan, Martin Brady, Allan H. Friedman, Ira Past...
https://www.researchgate.net/publication/221836741_Convection_Enhanced_Delivery_of_Macromolecules_for_Brain_Tumors
The blood brain barrier (BBB) poses a significant challenge for drug delivery of macromolecules into the brain. Convection-enhanced delivery (CED) circumvents the BBB through direct intracerebral ...
https://www.jstor.org/stable/2364175
Convection-enhanced delivery of macromolecules in the brain (interstitial infusion/bulk flow/autoradiography) R. HUNT BOBO*, DOUGLAS W. LASKE*, AYTAC AKBASAK*, PAUL F. MORRISONt, ROBERT L. DEDRICKt, AND EDWARD H. OLDFIELD*t
https://link.springer.com/article/10.1007/s13311-017-0520-4
Mar 15, 2017 · Convection-enhanced delivery (CED) is a promising technique that generates a pressure gradient at the tip of an infusion catheter to deliver therapeutics directly through the interstitial spaces of the central nervous system. It addresses and offers solutions to many limitations of conventional techniques, allowing for delivery past the blood–brain barrier in a targeted and safe manner that ...Author: A. M. Mehta, A. M. Sonabend, J. N. Bruce
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