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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657605/
Convection-enhanced delivery for the treatment of brain tumors Abstract. Convection-enhanced delivery to brain parenchyma. Catheters for CED. Leakage of infusates during CED. Pharmacologic formulation of CED infusates. Canine model for CED. Anti-GBM cytotoxins for CED.Author: Waldemar Debinski, Stephen B Tatter
https://www.ncbi.nlm.nih.gov/pubmed/19831841
Convection-enhanced delivery (CED) has been designed to overcome some of the difficulties so that pharmacological agents that would not normally cross the BBB can be used for treatment. Drugs are delivered through one to several catheters placed stereotactically directly within the tumor mass or around the tumor or the resection cavity.Author: Waldemar Debinski, Stephen B Tatter
https://braintumorcenter.ucsf.edu/treatment/experimental-diagnostics-therapies/convection-enhanced-delivery
Convection Enhanced Delivery. Using standard chemotherapy on brain tumors is challenging, considering that many of these drugs (administered as a pill, or injected intravenously) do not enter the brain easily. Increasing dosages would not work either, since these medications would reach toxic concentrations in the body before reaching effective...
https://www.medscape.com/viewarticle/712531
Nov 06, 2019 · The brain is highly accessible for nutrients and oxygen, however delivery of drugs to malignant brain tumors is a very challenging task. Convection-enhanced delivery (CED) has been designed to overcome some of the difficulties so that pharmacological agents that would not normally cross the BBB can be used for treatment.
https://www.medscape.com/viewarticle/712531_2
Oct 15, 2019 · Convection-enhanced delivery (CED) enables administration of anti-GBM drugs directly to the tumor and thus circumvents the problem with BBB penetration.
https://www.sciencedirect.com/science/article/pii/S014296120900009X
Review Convection-enhanced delivery of nanocarriers for the treatment of brain tumors 1. Introduction. The incidence of primary central nervous system tumors (PCNST) is increasing,... 2. Technical approach of convection-enhanced delivery. 3. The convection-enhanced delivery of nanocarriers. 4. ...Author: Emilie Allard, Catherine Passirani, Jean-Pierre Benoit
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483037/
Mar 05, 2015 · Hence, direct delivery of therapeutics to the brain and to brain tumors is an active area of investigation. One of these techniques, convection-enhanced delivery (CED), involves the implantation of catheters through which conventional and novel therapeutic formulations can be delivered using continuous, low–positive-pressure bulk flow.Author: Michael A. Vogelbaum, Manish K. Aghi
https://www.ncbi.nlm.nih.gov/pubmed/19168213
Primary brain tumors have a significant infiltrative capacity as their reappearance after resection usually occurs within 2cm of the tumor margin. Local delivery method such as Convection-Enhanced Delivery (CED) has been introduced to avoid this recurrence by delivering active molecules via positive-pressure methods.Author: Emilie Allard, Catherine Passirani, Jean-Pierre Benoit
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