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https://www.researchgate.net/publication/13300088_A_Controlled-Release_Microchip
A prototype microchip for controlled release showing the shape of a single reservoir.a, Fabrication of these microchips began by depositing 0.12 m of low stress, silicon-rich nitride on both sides ...
https://stm.sciencemag.org/content/4/122/122ra21.full
Feb 22, 2012 · The first clinical trial of an implantable microchip-based drug delivery device is discussed. Human parathyroid hormone fragment (1–34) [hPTH(1–34)] was delivered from the device in vivo. hPTH(1–34) is the only approved anabolic osteoporosis treatment, but requires daily injections, making patient compliance an obstacle to effective treatment. Furthermore, a net increase in bone mineral ...Author: Robert Farra, Norman F. Sheppard, Laura McCabe, Robert M. Neer, James M. Anderson, John T. Santini, ...
https://www.nature.com/articles/16898
Much previous work in methods of achieving complex drug-release patterns has focused on pulsatile release from polymeric materials in response to specific stimuli1, such as electric2,3,4,5 or ...Author: John T. Santini, Michael J. Cima, Robert Langer
http://www.thepharmajournal.com/vol1Issue10/Issue_dec_2012/1.1.pdf
Microchip drug delivery system is the most wonderful system of delivering the drug for a great span of time without the intervention of the patient to whom it is fixed. It consists of varied number of sockets containing drug (generally ranging from 50-300) which release the drug at the fixed intervals each at a …
https://www.webmd.com/osteoporosis/news/20120216/drug-delivery-microchip
Feb 16, 2012 · An experimental, implanted drug-delivery microchip that releases medication on command from an external wireless control could one day free patients …Author: Salynn Boyles
https://www.hindawi.com/journals/bmri/2016/1743472/
With the objective of improving efficacy and morbidity, device manufacturers incorporate chemicals or drugs into medical implants. Using multiple reservoirs of discrete drug doses, microchips represent a new technology capable of on-demand release of various drugs over long periods of time. Herein, we review drug delivery systems, how microchips work, recent investigations, and future ...Author: Adam E. M. Eltorai, Henry Fox, Emily McGurrin, Stephanie Guang
https://www.nature.com/articles/16898?error=cookies_not_supported&code=78e689f0-e905-4a39-8a14-602550acf483
Jan 28, 1999 · Controlled release from our microchip involves no moving parts. Release from a particular reservoir is initiated by applying an electric potential between the anode membrane covering that ...Author: John T. Santini, Michael J. Cima, Robert Langer
https://www.microchip.com/design-centers/medical/applications/medical-drug-delivery-pumps
There are several types of medical drug delivery pumps. For example, an infusion pump is a medical device used to deliver fluids into a patient’s body in a controlled manner. There are many different types of infusion pumps, which are used for in a variety of environments and for a variety of purposes.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914739/
Jun 07, 2016 · In 1998, the US Patent “Microchip Drug Delivery Devices” was awarded to Santini Jr. et al., which first outlined the parameters of a multireservoir microchip system with an active release system . In 1999, Santini Jr. et al. debuted the first electrochemically activated drug delivery microchip .
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