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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142099/
Sep 28, 2014 · The controlled drug delivery technology has progressed over the last six decades. It began in 1952 with the introduction of the first sustained release formulation. The 1st generation (1950-1980) of drug delivery was focused on developing oral and transdermal sustained release systems and establishing the controlled drug release mechanisms.Author: Kinam Park
http://www.thepharmajournal.com/vol1Issue10/Issue_dec_2012/3.1.pdf
of the original controlled-release systems was to achieve a delivery profile that would yield a high blood level of the drug over a long period of time. With traditional drug delivery systems, the drug level in the blood follows the in which the level rises after each administration of the drug and
https://www.corbion.com/biomedical/applications/controlled-release-systems
The PURASORB polymers are ideal resorbable excipients for controlled release drug delivery systems – enabling patients to control dosage over days, weeks, or months with a single injection.
http://www.maynepharma.com/our-capabilities/specialty-technologies/controlled-release-delivery-system/
Controlled Release Delivery System Mayne Pharma specializes in the formulation and production of technologies that permit controlled-release of active pharmaceutical ingredients (APIs) in pellets. We focus on all drugs in pellet form achieving a highly desired physicochemical and pharmacokinetic profile, which ensures finely controlled dosing and optimal drug efficacy.
https://testmyprep.com/subject/biology/classification-of-controlled-release-delivery
Controlled release medication delivery is defined as release of the medication in a predesigned manner. The main behind the handled release delivery of drugs is to encourage restorative benefits at exactly the same time reducing toxic effects. Controlled release medicine delivery is used to minimize unwanted fluctuation of drug levels.
https://www.pharmatutor.org/articles/oral-controlled-release-drug-delivery-system-review
The basic rationale of a controlled release drug delivery system is to optimize the biopharmaceutics, pharmacokinetics, and pharmacodynamics properties of a drug in such a way that its utility is maximized through reduction in side effects and cure or control of disease condition in the shortest possible time by using smallest quantity of drug, administered by most suitable route.Author: M Gahlyan, S Jain
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