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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142099/
Sep 28, 2014 · The controlled drug delivery technology has progressed over the last six decades. It began in 1952 with the introduction of the first sustained release formulation. The 1st generation (1950-1980) of drug delivery was focused on developing oral and transdermal sustained release systems and establishing the controlled drug release mechanisms.Author: Kinam Park
https://www.nibib.nih.gov/science-education/science-topics/drug-delivery-systems-getting-drugs-their-targets-controlled-manner
Drug delivery systems are engineered technologies for the targeted delivery and/or controlled release of therapeutic agents. Drugs have long been used to improve health and extend lives. The practice of drug delivery has changed dramatically in the past few decades and even greater changes are anticipated in the near future.
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/controlled-drug-release
The main benefits of controlled release drug delivery systems include maintenance of optimum drug concentration and augmented duration of therapeutic effect, improved efficiency of treatment with lesser amount of drug, reduced side-effects, less frequent administration, increased patient convenience and compliance, reduced drug plasma level fluctuation, and maintenance of a steady-state plasma level of the drug …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135015/
Controlled and targeted drug delivery improves the bio-distribution of a drug, increases the circulation half-life and also protects the drug from the microenvironment, to increase the efficiency and reduce related side effects.Author: Sharma T. Sanjay, Maowei Dou, Guanglei Fu, Feng Xu, Xiu Jun Li
https://www.sciencedirect.com/science/article/pii/S0168365914002508
Controlled drug delivery technology has progressed over the last six decades. This progression began in 1952 with the introduction of the first sustained release formulation. The 1st generation of drug delivery (1950–1980) focused on developing oral and transdermal sustained release systems and establishing controlled drug release mechanisms.
https://www.routledge.com/Controlled-Drug-Delivery-Systems-1st-Edition/Opara/p/book/9780367187170
Discusses various controlled drug delivery systems, including sustained release delivery systems and pulse or delayed release, e.g. to target different regions of the gastrointestinal tract.
https://www.pharmatutor.org/articles/oral-controlled-release-drug-delivery-system-review
The basic rationale of a controlled release drug delivery system is to optimize the biopharmaceutics, pharmacokinetics, and pharmacodynamics properties of a drug in such a way that its utility is maximized through reduction in side effects and cure or control of disease condition in the shortest possible time by using smallest quantity of drug, administered by most suitable route.Author: M Gahlyan, S Jain
http://www.thepharmajournal.com/vol1Issue10/Issue_dec_2012/3.1.pdf
INTRODUCTION: Controlled drug delivery systems can include the maintenance of drug levels within a desired range, the need for fewer administrations, optimal use of the drug in question, and increased patient compliance. higher cost of controlled-release systems compared with …
https://www.medindia.net/patients/patientinfo/drug-delivery-system.htm
drug delivery system or a controlled release technology. The technology uses binding chemicals that release drugs at a controlled rate at the targeted location in the body. are used to transport a drug to a specific part of the body. The concept of drug delivery is precisely integrated with the dosage of a drug and route of administration.
https://www.slideshare.net/ganapati123/controlled-drug-delivery-systems
Mar 18, 2013 · CONTROLLED DRUG DELIVERY SYSTEMS 1. 1 2. Controlled release• To achieve prolong therapeutic effect.• Implies predictability in drug release kinetics.• Deliver the drug at pre determined rate, locally or systematically. 2 3. Advantages• Improve patient convenience.• Reduction in fluctuation in steady state level.•
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