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https://pubs.rsc.org/en/content/articlelanding/2011/cc/c1cc10991j#!
Loosely aggregated conjugated polymer nanoparticles (CPNs) were used as nontoxic and efficient small interfering RNA (siRNA) delivery vehicles with delivery visualization. A significant down regulation (94%) of a target gene was achieved by transfection of HeLa cells with the CPNs/siRNA complexes, supporting CPN as a promising siRNA delivery carrier.
http://www.rsc.org/suppdata/cc/c1/c1cc10991j/c1cc10991j.pdf
Conjugated polymer nanoparticles for small interfering RNA delivery . Joong Ho Moon,*,† Eladio Mendez, † Yong Kim‡, and Aman Kaur† †Department of Chemistry and Biochemistry, Florida International University, 11200 SW 8thSt., Miami, FL 33199 ‡ Division of Or al Biology and Medicine, UCLA School of Dentistry, Dental Research Institute, UCLA’s
https://www.researchgate.net/publication/51240491_Conjugated_polymer_nanoparticles_for_small_interfering_RNA_delivery
Loosely aggregated conjugated polymer nanoparticles (CPNs) were used as nontoxic and efficient small interfering RNA (siRNA) delivery vehicles with delivery visualization.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023792/
CPNs are fluorescent conjugated polymer nanoparticles and are valuable for live plant cell imaging. Their inherent photophysical properties include high fluorescence quantum yield, large extinction coefficient, and efficient optical signal transduction making them a superior choice for biological imaging [22,23]. Furthermore, we demonstrate that CPNs are an effective transfection vehicle for delivery of …Author: Asitha T Silva, Alien Nguyen, Changming Ye, Jeanmarie Verchot, Joong Ho Moon
http://digitalcommons.fiu.edu/cgi/viewcontent.cgi?article=1003&context=chemistry_fac
Conjugated polymer nanoparticles for effective siRNA delivery to tobacco BY-2 protoplasts Asitha T Silva1, Alien Nguyen2, Changming Ye1, Jeanmarie Verchot1*, Joong Ho Moon2* Abstract Background: Post transcriptional gene silencing (PTGS) is a mechanism harnessed by plant biologists to knock
https://pubs.acs.org/doi/full/10.1021/nl9009793
First, gold nanoparticles were modified with the hydrophilic polymer poly(ethylene glycol) (PEG), and then small interfering RNA (siRNA) was conjugated to the nanoparticles via biodegradable disulfide linkages, with ∼30 strands of siRNA per nanoparticle.Author: Jae-Seung Lee, Jordan J. Green, Kevin T. Love, Joel Sunshine, Robert Langer, Daniel G. Anderson
https://www.researchgate.net/publication/335283847_Conjugated_Polymer_Dots_for_Biocompatible_siRNA_Delivery
Loosely aggregated conjugated polymer nanoparticles (CPNs) were used as nontoxic and efficient small interfering RNA (siRNA) delivery vehicles with delivery visualization.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728206/
First, gold nanoparticles were modified with the hydrophilic polymer poly (ethylene glycol) (PEG), and then small interfering RNA (siRNA) was conjugated to the nanoparticles via biodegradable disulfide linkages, with ~30 strands of siRNA per nanoparticle. The particles were then coated with a library of end-modified poly ( β -amino ester)s...Author: Jae-Seung Lee, Jordan J. Green, Kevin T. Love, Joel Sunshine, Robert Langer, Daniel G. Anderson
https://www.sciencedirect.com/science/article/pii/S0927776520301211
FA-based active gene delivery systems might serve as a vector to deliver small interfering RNA ... K. Li, Y. Hu, B. LiuBright far-red/near-infrared conjugated polymer nanoparticles for in vivo ... R.K. RoederEffects of bisphosphonate ligands and PEGylation on targeted delivery of gold nanoparticles for contrast-enhanced radiographic ...Author: Xin Huang, Wei Wu, Wenbo Yang, Xiangcheng Qing, Zengwu Shao
https://en.wikipedia.org/wiki/Small_interfering_RNA
Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded RNA non-coding RNA molecules, 20-25 base pairs in length, similar to miRNA, and operating within the RNA interference (RNAi) pathway. It interferes with the expression of specific genes with complementary nucleotide sequences by degrading mRNA after transcription, preventing ...
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