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https://www.sciencedirect.com/science/article/pii/S0168365904004122
Comparison of antisense oligonucleotide drug delivery systems 1. Introduction. Since the late 1970s antisense oligonucleotides... 2. Material and methods. We used unmodified ONs which were synthesized by Biospring (Frankfurt,... 3. Results and discussion. We investigated different types of ...Author: Jörg Weyermann, Dirk Lochmann, Andreas Zimmer
https://www.ncbi.nlm.nih.gov/pubmed/15567506
Dec 10, 2004 · Antisense oligonucleotides (AS-ONs) are specific drugs to inhibit gene expression at the transcriptional level. They possess a poor bioavailability and can be degraded by nucleases very rapidly. Therefore, a strong need for the development of oligonucleotide drug delivery systems …Author: Jörg Weyermann, Dirk Lochmann, Andreas Zimmer
https://www.researchgate.net/publication/8159009_Comparison_of_antisense_oligonucleotide_drug_delivery_systems
Antisense oligonucleotides (AS-ONs) are specific drugs to inhibit gene expression at the transcriptional level. They possess a poor bioavailability and can be degraded by nucleases very rapidly. Therefore, a strong need for the development of oligonucleotide drug delivery systems exists.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664895/
Oligonucleotides including antisense oligonucleotides and siRNA are emerging as promising therapeutic agents against a variety of diseases. Effective delivery of these molecules is critical to their successful clinical application. Targeted systems can greatly improve the efficiency and specificity of oligonucleotides delivery.Author: Bo Yu, Xiaobin Zhao, L. James Lee, Robert J. Lee
https://www.mdpi.com/2218-273X/10/4/553/pdf
Chitosan Nanocomplexes for the Delivery of ENaC Antisense Oligonucleotides to Airway Epithelial Cells A. Katharina Kolonko 1,*, ... Nanoscale drug delivery systems exhibit a broad range of applications and ... M. Live-cell imaging to compare the transfection and gene silencing efficiency of calcium phosphate nanoparticles and a liposomal ...
https://www.frontiersin.org/articles/10.3389/fchem.2014.00087/full
Oct 14, 2014 · These are both single-stranded antisense oligonucleotide drugs (most commonly known as AONs) that together with siRNA (a double-stranded oligonucleotide) make up, at present, the therapeutic antisense oligonucleotide field. In this paper more emphasis will be put on AONs due to their longer time in development and history of clinical trials.Author: Pedro M. D. Moreno, Ana P. Pêgo
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