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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215502/
Feb 07, 2010 · Drug Delivery Index (DDI) and Clinical Evaluation of Colon-Specific Drug Delivery Systems DDI is a calculated pharmacokinetic parameter, following single or multiple dose of oral colonic prodrugs. DDI is the relative ratio of RCE (Relative colonic tissue exposure to the drug) to RSC (Relative amount of drug in blood i.e. that is relative systemic exposal to the drug).Author: Anil K. Philip, Betty Philip
https://www.sciencedirect.com/science/article/abs/pii/0169409X9190051D
The delivery of drugs to the colon has a number of important implications in the field of pharmacotherapy. Several diseases, including IBD, can be treated more effectively by local delivery of antiinflammatory agents to the large intestine.Author: David R. Friend
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508299/
Jun 13, 2015 · Colon-specific drug delivery systems (CDDS) are desirable for the treatment of a range of local diseases such as ulcerative colitis, Crohn’s disease, irritable bowel syndrome, chronic pancreatitis, and colonic cancer. In addition, the colon can be a potential site for the systemic absorption of several drugs to treat non-colonic conditions.Author: Seth Amidon, Jack E. Brown, Vivek S. Dave
https://www.japsonline.com/admin/php/uploads/363_pdf.pdf
Colon specific drug delivery system has attracted considerable attention for the past few years in order to develop drug delivery systems that are able to release drugs specifically in the colon in a predictable and reproducible manner. The colon is a site where both local and systemic delivery of drugs can take place.
https://drug-dev.com/colon-specific-delivery-toward-reliable-colon-specific-drug-delivery/
Targeted drug delivery in the digestive tract had long been a desired goal. To date, drug release triggered by pH value, time, enzymes, or intestinal pressure is standard practice. Unfortunately, such physiological triggering suffers from ill-defined parameters, which may vary considerably from individual to individual, and also depends on a patient’s state of health.1
http://shodhganga.inflibnet.ac.in/bitstream/10603/8337/8/08_chapter%201.pdf
1.1 COLON SPECIFIC DRUG DELIVERY SYSTEM (CSDDS) The major goal of any drug delivery system is to supply a therapeutic amount of drug to a target site in a body, so that the desired drug concentration can be achieved swiftly and then maintained. Targeted drug delivery implies selective and effective localization of drug into the
https://www.slideshare.net/bharathpharmacist/colon-specific-drug-delivery-system-39685838
Sep 30, 2014 · Drug absorption in the colon. Approaches to colon-specific drug delivery . Evaluation of colon specific drug delivery systems 3. Introduction:- Definition:-Colon drug delivery system refers to targeted delivery of drug in to the lower parts of GI tract , mainly large intestine.
https://www.tandfonline.com/doi/abs/10.1517/17425247.4.5.547
Sep 16, 2016 · Azo compounds have the potential to act as drug carriers that facilitate the selective release of therapeutic agents to the colon, and also to effect the oral administration of those macromolecular drugs that require colon-specific drug delivery.Author: Marta Roldo, Eugen Barbu, James F Brown, David W Laight, John D Smart, John Tsibouklis
https://www.researchgate.net/publication/244994822_Colon_targeted_drug_delivery_systems-A_review
There is a considerable interest in the colon specific drug delivery in order to treat diseases of the large intestine, such as colitis, colon cancer, constipation, irritable bowel syndrome, and infectious diseases (16) . To achieve successful colonic delivery, the drug needs to be protected from absorption and /or...
https://pharmawiki.in/m-pharm-pharmaceutics-notes-evaluation-of-colon-specific-drug-delivey-systems-pdf/
Oct 31, 2017 · In vivo evaluation of colon-specific drug delivery systems As in other controlled release delivery systems, the successful development of a colon-specific drug delivery system is ultimately determined by its ability to achieve colon-specific drug release and …
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