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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215502/
Feb 07, 2010 · The colon is a site where both local and systemic delivery of drugs can take place. Local delivery allows topical treatment of inflammatory bowel disease. However, treatment can be made effective if the drugs can be targeted directly into the colon, thereby ...Author: Anil K. Philip, Betty Philip
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508299/
Jun 13, 2015 · Colon-specific drug delivery systems (CDDS) are desirable for the treatment of a range of local diseases such as ulcerative colitis, Crohn’s disease, irritable bowel syndrome, chronic pancreatitis, and colonic cancer. In addition, the colon can be a potential site for the systemic absorption of several drugs to treat non-colonic conditions.Author: Seth Amidon, Jack E. Brown, Vivek S. Dave
https://www.capsugel.com/biopharmaceutical-technologies/colonic-delivery-technologies
Capsugel offers multiparticulate and capsule-coating technologies to achieve colonic drug delivery. This targeted delivery option has received increased attention not only for treatment of colon-specific diseases such as irritable bowel disease (IBD), but also to take advantage of the colon’s absorptive surface area and conditions to deliver specific drugs and treat specific indications.
https://www.sciencedirect.com/science/article/pii/S1773224714000069
Colon delivery systems based on coated pellets have been designed to exploit physiological pH changes within the small and large bowel, undergo enzymatic degradation by the colonic microbiota or delay the onset of release according to the time required for dosage forms to reach the colon.Author: Luca Palugan, Matteo Cerea, Lucia Zema, Andrea Gazzaniga, Alessandra Maroni
https://www.wndu.com/content/news/Cutting-edge-chemo-delivery-for-colorectal-cancer-566283841.html
Dec 17, 2019 · Patients with colon cancer that spread to the liver had few options if standard chemotherapy stopped working. ... CUTTING-EDGE CHEMO DELIVERY FOR COLORECTAL CANCER REPORT: MB #4666.
https://www.sciencedirect.com/science/article/pii/B9780081025536000258
Targeted delivery of drugs to the colon has recently gained importance for the treatment of variety of diseases like Crohn’s disease, ulcerative colitis, colorectal cancer, and to deliver protein and peptides.Author: Somasree Ray
https://www.nbcdfw.com/news/health/cutting-edge-chemo-delivery-for-colorectal-cancer/2272591/
Dec 12, 2019 · Cutting-Edge Chemo Delivery for Colorectal Cancer ... Patients with colon cancer that spread to the liver had few options if standard chemotherapy stopped …
https://www.tandfonline.com/doi/full/10.1517/17425247.2011.597739
Oct 19, 2008 · Oral colon-targeted drug delivery systems have gained enormous attention among researchers in the last two decades. The significance of this site-specific drug delivery system can be measured by its usefulness for delivering a variety of therapeutic agents, both for the treatment of local diseases or for systemic therapies. With the arrival of newer innovations, a large number of …Author: Mayur M Patel
https://www.tandfonline.com/doi/abs/10.1080/10408690490478091
Jul 06, 2009 · Colon-targeted delivery of bioactives has recently gained importance in addressing specific needs in the therapy of colon-based diseases. Many approaches have been attempted for the development of colon-specific delivery systems, with not much success in the past. Recent research into the utilization of the metabolic activity and the colonic microenvironment in the lower gastrointestinal …Author: Shantha L. Kosaraju
https://academic.oup.com/ibdjournal/article/24/7/1401/4999330
May 18, 2018 · The advantages of nanoparticle delivery systems over conventional colon-targeted approaches include improved efficacy, reduced toxicity, and enhanced bio-distribution. 42 This section reviews current orally administered nano-delivery systems for UC, involving different strategies for the delivery of targeted drugs to inflamed colon tissue .Author: Mingzhen Zhang, Didier Merlin
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