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https://www.sciencedirect.com/science/article/pii/S1773224714000069
Colon delivery systems based on coated pellets have been designed to exploit physiological pH changes within the small and large bowel, undergo enzymatic degradation by the colonic microbiota or delay the onset of release according to the time required for dosage forms to reach the colon.Author: Luca Palugan, Matteo Cerea, Lucia Zema, Andrea Gazzaniga, Alessandra Maroni
https://www.researchgate.net/publication/272390908_Coated_pellets_for_oral_colon_delivery
Because of their spherical or pseudo-spherical shape, uniform size and smooth surface, pellets are of particular interest for use as cores in the manufacturing of coated oral delivery systems.
https://www.sciencedirect.com/science/article/abs/pii/S1773224714000069
Because of their spherical or pseudo-spherical shape, uniform size and smooth surface, pellets are of particular interest for use as cores in the manufacturing of coated oral delivery systems. When intended for colon delivery, pellet formulations may be provided with enzymatically-degradable, pH-sensitive or time-controlled polymer coatings.Author: Luca Palugan, Matteo Cerea, Lucia Zema, Andrea Gazzaniga, Alessandra Maroni
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215502/
Feb 07, 2010 · Colon Targeted Drug Delivery Systems: A Review on Primary and Novel Approaches. ... a. pH Sensitive Polymer Coated Drug Delivery to the Colon . ... It has therefore been concluded that drug dissolution in the colon could present a problem in relation to colon-specific oral drug delivery systems.Author: Anil K. Philip, Betty Philip
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813129/
Pectin Film Coated Pellets for Colon-targeted Delivery of Budesonide: ... However, as a general principle, the acceptance and compliance of topical preparations such as enema is low and local delivery of drugs in the colon after oral administration may lead to better efficacy/side effect profiles and may improve patient›s compliance . In the ...Author: Jaleh Varshosaz, Jaber Emami, Naser Tavakoli, Mohsen Minaiyan, Nakisa Rahmani, Farid Dorkoosh, Parvi...
https://www.tandfonline.com/doi/pdf/10.1080/17425247.2017.1360864
4. Gazzaniga A, Maroni A, Sangalli ME, et al. Time-controlled oral delivery systems for colon targeting. Expert Opin Drug Deliv. 2006;3:583–597. † First and only review article on time-dependent formulations for oral colon delivery. 5. Palugan L, Cerea M, Zema L, et al. Coated pellets for oral colon delivery. J Drug Deliv Sci Technol. 2015 ...
https://www.researchgate.net/publication/258703382_Pectin_Film_Coated_Pellets_for_Colon-targeted_Delivery_of_Budesonide_In-vitroIn-vivo_Evaluation_in_Induced_Ulcerative_Colitis_in_Rat
Pectin Film Coated Pellets for Colon-targeted Delivery of Budesonide: In-vitro/In-vivo Evaluation in Induced Ulcerative Colitis in Rat Jaleh V arshosaz a , Jaber Emami a , Naser Tavakoli a ...
https://www.hindawi.com/journals/jdd/2012/905191/
Another important parameter that should be considered is choosing of proper cushioning agent to prevent of undesirable fusion of coated pellets by the compression . In this study, a colon delivery formulation of budesonide was designed based on pH and time-dependent approach where film-coated pellets were compressed into multiparticulate tablets.Author: Jaleh Varshosaz, Jaber Emami, Naser Tavakoli, Mohsen Minaiyan, Nakisa Rahmani, Farid Dorkoosh
https://pubs.acs.org/doi/10.1021/jf2005468
An oral colon-targeting controlled release system based on resistant starch acetate (RSA) as a film-coating material was developed. The RSA was successfully synthesized, and its digestion resistibility could be improved by increasing the degree of substitution (DS), which was favorable for the colon-targeting purpose. As a delivery carrier material, the characteristics of RSA were investigated ...Author: Huayin Pu, Ling Chen, Xiaoxi Li, Fengwei Xie, Long Yu, Lin Li
https://healthcare.evonik.com/product/health-care/en/custom-solutions/oral-drug-delivery/eudratec-col/
With the first oral drug product utilizing EUDRATEC® COL having reached the market in 2017, the technology represents a reliable and commercially proven system to enable colon targeted drug delivery. EUDRATEC® COL is suitable for use as coated pellets that can be filled into capsules and compressed into multiparticulates, as well as other ...
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