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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2833276/
To further examine whether the efficient knockdown of Bcl-2 mRNA can effectively increase the chemotherapy efficacy of Dox, the cellular cytotoxicity of free Dox and MSN-Dox-G2 with or without Bcl-2 siRNA was assessed by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay.Author: Alex M. Chen, Min Zhang, Dongguang Wei, Dirk Stueber, Oleh Taratula, Tamara Minko, Huixin He
https://www.sciencedirect.com/science/article/pii/S014296121400132X
The over-expression of Bcl-2 renders cancer cells resistance to DOX-induced apoptosis. Previous studies showed that siRNA targeting on Bcl-2 and antisense Bcl-2 oligonucleotide increased the susceptibility of cancer cells to DOX-induced apoptosis and co-delivery of DOX and Bcl-2 siRNA by nanoparticles enhances chemotherapy efficacy , .Author: Xiongwei Deng, Minjun Cao, Jiakun Zhang, Kelei Hu, Zhaoxia Yin, Zhixiang Zhou, Xiangqian Xiao, Yishu...
http://onlinelibrary.wiley.com/store/10.1002/smll.200900621/asset/supinfo/smll_200900621_sm_suppdata.pdf?v=1&s=1ee7d29e5ac46c1a25891315e52171888b655a5c
G2 amine-terminated PAMAM dendrimer, doxorubicin hydrochloride and other chemicals used in this study were purchased from Sigma Aldrich (Milwaukee, WI), and used without further purification. siRNA that are sequence specific for human Bcl-2 mRNA was custom synthesized by Ambion (Austin, TX).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503501/
Inhibition of cell proliferation through an ATP-responsive co-delivery system of doxorubicin and Bcl-2 siRNA. ... aptamer, doxorubicin, Bcl-2 siRNA, anti-proliferation ... et al. Efficient delivery of Bcl-2-targeted siRNA using cationic polymer nanoparticles: downregulating mRNA expression level and sensitizing cancer cells to anticancer drug. ...Author: Jianxu Zhang, Yudi Wang, Jiawen Chen, Xiao Liang, Haobo Han, Yan Yang, Quanshun Li, Yanbo Wang
https://www.sciencedirect.com/science/article/pii/S0142961213000811
Polypeptide cationic micelles mediated co-delivery of docetaxel and siRNA for synergistic tumor therapy ... A reduction in Bcl-2 mRNA was subsequently accompanied by decreased Bcl-2 protein ... D. Stueber, O. Taratula, T. Minko, et al.Co-delivery of doxorubicin and bcl-2 siRNA by mesoporous silica nanoparticles enhances the efficacy of ...Author: Cuifang Zheng, Mingbin Zheng, Ping Gong, Jizhe Deng, Huqiang Yi, Pengfei Zhang, Yijuan Zhang, Peng L...
https://www.nature.com/articles/srep23859
Mar 31, 2016 · Chen, A. M. et al. Co-delivery of doxorubicin and bcl-2 siRNA by mesoporous silica nanoparticles enhances the efficacy of chemotherapy in multidrug-resistant cancer …Author: Chun-ge Zhang, Wen-jing Zhu, Yang Liu, Zhi-qiang Yuan, Shu-di Yang, Wei-liang Chen, Ji-zhao Li, Xiao...
https://www.researchgate.net/publication/26836952_Co-delivery_of_Doxorubicin_and_Bcl-2_siRNA_by_Mesoporous_Silica_Nanoparticles_Enhances_the_Efficacy_of_Chemotherapy_in_Multidrug-Resistant_Cancer_Cells
Co-delivery of Doxorubicin and Bcl-2 siRNA by Mesoporous Silica Nanoparticles Enhances the Efficacy of Chemotherapy in Multidrug-Resistant Cancer Cells.
https://www.dovepress.com/doxorubicin-and-anti-vegf-sirna-co-delivery-via-nano-graphene-oxide-fo-peer-reviewed-fulltext-article-IJN
Doxorubicin and anti-VEGF siRNA co-delivery via nano-graphene oxide for enhanced cancer therapy in vitro and in vivo Qi Sun,1–3 Xiaoli Wang,1–3 Chunying Cui,1–3 Jing Li,1–3 Yifan Wang1–3 1Department of Pharmaceutics, School of Pharmaceutical Sciences, Capital Medical University, Beijing, China; 2Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Beijing, China ...Author: Qi Sun, Xiaoli Wang, Chunying Cui, Jing Li, Yifan Wang
https://onlinelibrary.wiley.com/doi/10.1002/smll.201303951
Mar 25, 2014 · Guixiang Tian, Ruiyan Pan, Bo Zhang, Meihua Qu, Bo Lian, Hong Jiang, Zhiqin Gao and Jingliang Wu, Liver-Targeted Combination Therapy Basing on Glycyrrhizic Acid-Modified DSPE-PEG-PEI Nanoparticles for Co-delivery of Doxorubicin and Bcl-2 siRNA, Frontiers in Pharmacology, 10.3389/fphar.2019.00004, 10, (2019).Author: Weicai Chen, Yuanyuan Yuan, Du Cheng, Jifeng Chen, Lu Wang, Xintao Shuai
https://www.researchgate.net/publication/51775975_Multifunctional_nanocarrier_mediated_co-delivery_of_doxorubicin_and_siRNA_for_synergistic_enhancement_of_glioma_apoptosis_in_rat
Multifunctional nanocarrier mediated co-delivery of doxorubicin and siRNA for synergistic enhancement of glioma apoptosis in rat ... significantly downregulated the expression of BCL-2 mRNA and ...
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