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https://www.researchgate.net/publication/51561273_Chronotherapeutic_Drug_Delivery_Systems_-_An_Approach_to_Circadian_Rhythms_Diseases
Chronotherapeutic Drug Delivery Systems - An Approach to Circadian Rhythms Diseases Article · Literature Review (PDF Available) in Current Drug Delivery 8(6):622-33 · August 2011 with 882 Reads
https://www.the-scientist.com/features/circadian-rhythms-influence-treatment-effects-31746
Mar 31, 2017 · In wild-type mice, researchers found a timing-dependent response to the chemo drug cyclophosphamide, but they also found that animals lacking a circadian rhythm because of mutations in the clock genes BMAL1 and CLOCK did not show a time-dependent response. 15 Another study by Levi and colleagues, using circadian gene expression data for 27 ...
https://www.sciencedirect.com/science/article/pii/S0169409X07001251
Chronobiology, drug-delivery, and chronotherapeutics ... It is of interest that international guidelines for the diagnosis and treatment of asthma take into consideration the circadian rhythm in the manifestation and intensity of asthma symptoms . Evening or bedtime dosing is recommended for certain medications, some of which rely on special ...Author: Björn Lemmer
https://www.webmd.com/sleep-disorders/circadian-rhythm-disorder-medications
WebMD provides an overview of medications used to treat circadian rhythm disorders, including those caused by jet lag and shift work.
https://www.researchgate.net/publication/291351672_Circadian_rhythms_and_drug_delivery
Circadian rhythms and drug delivery. ... In case of arthritis there is a circadian rhythm in the plasma concentration of C-reactive protein and interleukin-6 of patients with rheumatoid arthritis ...
https://www.sciencedirect.com/science/article/pii/0168365991900318
Circadian rhythm in the forced expiratory volume (FEVi) in healthy controls and asthmatic patients. (Re- drawn from [10]). 12-1 Clock hour Fig. 2. Circadian rhythm in gastric acidity (H* ) m 14 healthy volunteers (controls) and 21 patients with active peptic ul- cer disease. (Redrawn from [ 14] ).Author: Björn Lemmer
https://www.ncbi.nlm.nih.gov/pubmed/20542067
Jul 31, 2010 · Disruption of circadian rhythms can be either the cause or the effect of various disorders including metabolic syndrome, inflammatory diseases and cancer. Furthermore, circadian rhythms in gene expression regulate both the action and disposition of various drugs and affect therapeutic efficacy and toxicity based on dosing time.Author: Siddharth Sukumaran, Richard R. Almon, Debra C. DuBois, William J. Jusko
https://www.ncbi.nlm.nih.gov/pubmed/26536406
Chronotherapy coordinates drug delivery with the circadian rhythm to enhance effectiveness and mitigate adverse effects and is achieved by delivering a drug when the system is most susceptible. Cancer is a chronotherapeutic disorder. Cancer treatment requires high doses of intravenous medication to kill cancerous cells; however, normal cells ...Author: Paul Librodo, Mitchell Buckley, Marilyn Luk, Andrea Bisso
http://med.stanford.edu/circadian.html
A large scale sleep-wake and circadian rhythm bioassay facility, with automated data tracking and analysis and a MPEG video monitoring system synchronized with EEG signals. ... In vivo microdialysis and a HPLC analysis system with concurrent sleep monitoring for neurotransmitter and regional drug delivery studies. Neurochemical assessments such ...
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