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https://onlinelibrary.wiley.com/doi/abs/10.1002/%28SICI%291097-4628%2819960314%2959%3A11%3C1795%3A%3AAID-APP16%3E3.0.CO%3B2-T
A mild chitosan/calcium alginate microencapsulation process, as applied to encapsulation of biological macromolecules such as albumin and insulin, was investigated. The microcapsules were derived by adding dropwise a protein‐containing sodium alginate mixture into a chitosan–CaCl 2 system. The beads containing a high concentration of entrapped bovine serum albumin (BSA) as more than 70% of the initial concentration were achieved via varying chitosan coat.Author: P. R. Hari, Thomas Chandy, Chandra P. Sharma
https://www.academia.edu/9325827/Chitosan_calcium_alginate_beads_for_oral_delivery_of_insulin
Chitosan/calcium—alginate beads for oral delivery of insulin
https://www.ncbi.nlm.nih.gov/pubmed/23567292
Oral delivery of insulin to the gastrointestinal tract is one of the most challenging issues, because it numerous barriers to overcome in order to create an effective system for insulin delivery. In the present study, insulin-loaded alginate/chitosan blend gel beads were prepared with different mass ratios.Author: Djamel Tahtat, Mohamed Mahlous, Samah Benamer, Assia Nacer Khodja, Habiba Oussedik-Oumehdi, Fatima L...
https://www.sciencedirect.com/science/article/pii/S0141813013001645
The presence of chitosan in the blend beads decreased the cumulative insulin release in gastric media and enhanced behavior of alginate/chitosan beads in intestinal medium due to the crosslinking. The alginate/chitosan beads crosslinked by glutaraldehyde may be considered as potential insulin carriers for oral drug delivery system.Author: Djamel Tahtat, Mohamed Mahlous, Samah Benamer, Assia Nacer Khodja, Habiba Oussedik-Oumehdi, Fatima L...
https://www.sciencedirect.com/science/article/pii/S092777651100703X
Novel delivery systems such as chitosan microspheres are promising for oral delivery of insulin. Using the Taguchi techniques, industries are able to greatly reduce product development cycle time for both design and production, therefore reducing costs and increasing profit.Author: S. Jose, J.F. Fangueiro, J. Smitha, T.A. Cinu, A.J. Chacko, K. Premaletha, E.B. Souto, E.B. Souto
https://www.sciencedirect.com/science/article/pii/S0939641110002596
The preparation procedure was observed, and the physical properties (particle size distribution, surface morphology, chitosan distribution, zeta potential) of the microspheres were characterized. Subsequently, the microspheres were employed to load model peptide of insulin.Author: Yueling Zhang, Wei Wei, Piping Lv, Lianyan Wang, Guanghui Ma
https://www.sciencedirect.com/science/article/pii/S0141813018307104
Chitosan coated calcium-alginate nanocapsules were developed for oral sustained delivery of liraglutide. The effect of coating components including sodium alginate, calcium chloride, and chitosan concentrations on the particle size was studied based on response surface methodology.Author: Fatemeh Shamekhi, Elnaz Tamjid, Khosro Khajeh
https://www.researchgate.net/publication/11307488_Encapsulation_of_insulin_in_chitosan-coated_alginate_beads_Oral_therapeutic_peptide_delivery
Encapsulation of insulin in chitosan-coated alginate beads: Oral therapeutic peptide delivery Article (PDF Available) in Artificial Cells Blood Substitutes and Biotechnology 30(3):229-37 · June ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850459/
Mar 19, 2010 · The optimum condition for preparation alginate–chitosan beads was alginate concentration of 3% and chitosan concentration of 0.25% at pH 5. The resulting bead formulation had a loading efficacy of 98.5% and average size of 1,501 μm, and scanning electron microscopy images showed spherical and smooth particles.Author: Sevgi Takka, Aybige Gürel
https://www.researchgate.net/publication/47382304_Preparation_and_evaluation_of_alginate-chitosan_microspheres_for_oral_delivery_of_insulin
Preparation and evaluation of alginate-chitosan microspheres for oral delivery of insulin. The alginate-chitosan microspheres with narrow size distribution were prepared by membrane emulsification technique in combination with ion (Ca(2+)) and polymer (chitosan) solidification.
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