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https://www.frontiersin.org/articles/10.3389/fphar.2020.00230/full
Chitosan (CTS) constitutes a promising area in treatment of nose-related diseases as a nasal drug delivery carrier. Astragalus polysaccharide (APS) significantly attenuates eosinophils and neutrophil-dominant airway inflammation, and it has a potential pharmaceutical application in the treatment of severe asthma. The purpose of this work was to prepare APS/CTS microspheres intended for nasal ...Author: Saisai Wang, Yuqing Sun, Jingjing Zhang, Xiaoming Cui, Zhilu Xu, Dejun Ding, Limin Zhao, Wentong Li,...
https://www.sciencedirect.com/science/article/pii/S0378517304006556
1. Introduction. Microspheres, in general, are investigated for targeted and controlled release drug delivery. A polymeric device allows for slow, controlled, and predictable drug release over a period of time and hence reduces the overall amount of drug needed (Illum, 2003).In nasal drug delivery, coupling of bioadhesive properties to microspheres is of great importance because of additional ...Author: Anita Martinac, Jelena Filipović-Grčić, Dario Voinovich, Beatrice Perissutti, Erica Franceschinis
https://www.ncbi.nlm.nih.gov/pubmed/15799226
Nasal delivery of insulin is an alternative route for administration of this drug. The objective of this study was preparation of chitosan microspheres for insulin nasal delivery. After preparation of insulin chitosan microspheres by emulsification-cross linking process, the effect of chitosan quantity (200-400mg), cross-linker type (ascorbic ...Author: J. Varshosaz, H. Sadrai, R. Alinagari
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374549/
Lorenzo-Lamosa et al. prepared the micro-encapsulated chitosan microspheres for colonic delivery of sodium diclofenac. Sodium diclofenac was entrapped into chitosan microcores by spray-drying and then, micro-encapsulated into Eudragit R L-100 and Eudragit R …
https://www.researchgate.net/publication/314238985_Chitosan_Based_Microspheres_of_Glibenclamide_Incorporated_in_in-situ_Gel_for_Nasal_Delivery_Optimization_and_in-vitro_Evaluation
glibenclamide nasal delivery with chitosan microspheres [8,9]. ... Nasal delivery is the logical choice for topical treatment of local diseases in the nose and paranasal sinuses such as allergic ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526152/
This review describes the various methods used to design and synthesize chitosan microspheres and recent updates on their potential applications for oral and nasal delivery of vaccines. The potential use of thiolated chitosan microspheres as next-generation mucosal vaccine carriers is also discussed.
https://www.sciencedirect.com/science/article/pii/S0927776511000506
Research highlights To develop and characterize chitosan mucoadhesive microspheres for nasal delivery. The Miat ® nasal insufflator was tested for reproducibility of dose delivered. The images of delivery sequences of powder clouds demonstrated an elongated puff. The core of clouds was homogeneous which provide effective distribution pattern.Author: Sanjay B. Patil, Krutika K. Sawant
https://www.researchgate.net/publication/7937260_Nasal_delivery_of_insulin_using_chitosan_microspheres
Nasal delivery of insulin is an alternative route for administration of this drug. The objective of this study was preparation of chitosan microspheres for insulin nasal delivery.
https://www.ijpsonline.com/articles/mucoadhesive-chitosan-microspheres-for-noninvasive-and-improved-nasal-delivery-of-insulin.html
Jul 19, 2006 · Mucoadhesive chitosan microspheres for non-invasive and improved nasal delivery of insulin, SK Jain, Nitin K Jain, Y Gupta, A Jain, D Jain, M ChaurasiaAuthor: SK Jain, Nitin K Jain, Y Gupta, A Jain, D Jain, M Chaurasia
https://www.researchgate.net/publication/49835783_Chitosan_microspheres_as_a_delivery_system_for_nasal_insufflation
The aim of the present study was to develop and characterize chitosan mucoadhesive microspheres for nasal delivery. The microspheres were prepared by emulsification-crosslinking method and ...
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