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https://www.sciencedirect.com/science/article/pii/S0022354915503729
The hypoglycemic effect started from 8 h after the administration of chitosan capsules when the capsules entered the colon, as evaluated by the transit time experiments with chitosan capsules. These findings suggest that chitosan capsules may be useful carriers for the colon-specific delivery of peptides including insulin.Author: Hideyuki Tozaki, Junta Komoike, Chika Tada, Takako Maruyama, Akira Terabe, Tsutomu Suzuki, Akira Yam...
https://www.sciencedirect.com/science/article/pii/S0168365902000846
Indeed, our previous study demonstrated that the chitosan capsule were effective for the colon-specific delivery of R68070, a new thromboxane synthase inhibitor and the treatment of TNBS-induced colitis . Furthermore, we developed a pharmacokinetic model of colon-specific drug delivery using chitosan capsules containing 5-ASA .Author: Hideyuki Tozaki, Tomokazu Odoriba, Naoki Okada, Takuya Fujita, Akira Terabe, Tsutomu Suzuki, Susumu ...
https://www.jstage.jst.go.jp/article/dds1986/12/5/12_5_311/_article
We reviewed the effectiveness of chitosan capsules for colon-specific delivery of insulin. The release of drug from the chitosan capsules was markedly increased in the presence of rat cecal contents, although no release from the capsules was observed in an artificial gastric juice and an artificial intestinal juice.
https://www.sciencedirect.com/science/article/pii/S0378517302003447
Chitosan has been used for colon-specific drug delivery as the forms of microspheres ( Lorenzo-Lamosa et al., 1998) and capsules ( Tozaki et al., 1997) because of its biodegradable properties by colonic bacteria. Under the presence of rat cecal contents in the …Author: Norihito Shimono, Toshihito Takatori, Masumi Ueda, Masaaki Mori, Yutaka Higashi, Yasuhiko Nakamura
https://www.jstage.jst.go.jp/article/dds1986/12/5/12_5_311/_article/references
38) Tozaki H, Komoike J, Tada C, Maruyama T, Terabe A, Suzuki T, Yamamoto A, Muranishi S : Chitosan capsules for colon-specific drug delivery : Improvement of insulin absorption from the …
https://www.researchgate.net/publication/11271434_Chitosan_capsules_for_colon-specific_drug_delivery_Enhanced_localization_of_5-aminosalicylic_acid_in_the_large_intestine_accelerates_healing_of_TNBS-induced_colitis_in_rats
The objective of this study was to achieve the colon-specific delivery of an anti-ulcerative colitis drug using chitosan capsules and to accelerate healing of 2,4,6-trinitrobenzene sulfonic acid ...
https://onlinelibrary.wiley.com/doi/abs/10.1211/0022357991776796
A pharmacokinetic model of colon‐specific drug delivery developed in a previous study has been validated by use of 5‐aminosalicylic acid (5‐ASA) as a model anti‐inflammatory drug. The simulation curves obtained from the pharmacokinetic model were in good agreement with experimental data obtained after oral administration of 5‐ASA‐containing chitosan capsules.Author: Hideyuki Tozaki, Takuya Fujita, Tomokazu Odoriba, Akira Terabe, Susumu Okabe, Shozo Muranishi, Akira...
http://www.nephro-pathology.com/uploads/1/0/0/4/10044970/chitosan_mediated_targeted_drug_delivery.pdf
rat cecal contents. Chitosan capsule-based formulations showed better therapeutic effect than a carboxymethylcellulose suspension in vivo. Chitosan capsules can also be used as carriers for colon-specificdelivery of absorption enhancers. Oral delivery of the absorption enhancer along with poorly absorbable drugs using chitosan capsules
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215502/
Feb 07, 2010 · Drug Delivery Index (DDI) and Clinical Evaluation of Colon-Specific Drug Delivery Systems DDI is a calculated pharmacokinetic parameter, following single or multiple dose of oral colonic prodrugs. DDI is the relative ratio of RCE (Relative colonic tissue exposure to the drug) to RSC (Relative amount of drug in blood i.e. that is relative systemic exposal to the drug).Author: Anil K. Philip, Betty Philip
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