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https://www.researchgate.net/publication/49660944_Chitosan_and_its_derivatives_for_gene_delivery
Chitosan and its derivatives as vehicles for drug delivery can achieve the purpose of sustained release and controlled release for drugs, improve the stability of drugs, and reduce adverse drug ...
https://www.researchgate.net/publication/226127503_Chitosan_and_its_derivatives_for_gene_delivery
Although chitosan and its derivatives have been frequently utilized as delivery vehicles for small interfering RNA (siRNA), it is challenging to improve the gene silencing efficiency of chitosan ...Author: Kuen Yong Lee
https://www.sciencedirect.com/science/article/pii/S0141813010003430
Chitosan is composed of randomly distributed α-(1-4)-linked d-glucosamine (deacetylated unit) and N-acetyl-d-glucosamine (acetylated unit).Partial deacetylation of chitin leads to the formation of different types of chitosan derivatives .It is a biocompatible, biodegradable polycationic polymer which has minimum immunogenicity and low cytotoxicity .Author: N. Saranya, A. Moorthi, S. Saravanan, M. Pandima Devi, N. Selvamurugan
https://www.ncbi.nlm.nih.gov/pubmed/21134396
Mar 01, 2011 · Chitosan, a natural polymer is nontoxic, biocompatible, and biodegradable and it is used as a support material for gene delivery. However, practical use of chitosan has been mainly limited to its unmodified forms, and thus modified chitosans can be used for the wide range of biomedical applications including the interaction and intracellular ...Author: N. Saranya, A. Moorthi, S. Saravanan, M. Pandima Devi, N. Selvamurugan
https://www.sciencedirect.com/science/article/pii/S0001868618303865
Chitosan and its derivatives are widely used to fabricate gene delivery vectors. Numerous studies have been conducted to construct gene vectors based on chitosan. This review will discuss the current progress toward strategies promoting the limitations and applications of chitosan in gene delivery systems and future prospects. 2. ChitosanAuthor: Di Chuan, Tao Jin, Rangrang Fan, Liangxue Zhou, Gang Guo
https://www.deepdyve.com/lp/elsevier/chitosan-and-its-derivatives-for-gene-delivery-pAhkLqdVDX
Mar 01, 2011 · Read "Chitosan and its derivatives for gene delivery, International Journal of Biological Macromolecules" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
https://link.springer.com/article/10.1007/BF03218774
Apr 01, 2007 · Non-viral vectors, including lipid- or polymer-based systems, have attracted much attention to date as a gene delivery vehicle, due to safety issues with viral vectors. Chitosan, a naturally existing cationic polymer, has shown great potential as a gene delivery carrier, as it has low immunogenicity and toxicity, excellent transcellular transport ability, and is relatively easy to chemically ...Author: Kuen Yong Lee
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627531/
Jun 25, 2019 · Although chitosan offers several favourable characteristics as an excellent gene carrier, unmodified chitosan is restricted by its low solubility in physiological conditions. Therefore, chitosan derivatives with enhanced solubility compared to chitosan for gene delivery have been well explored and summarized in several reviews [24,25,26].Author: Ye Cao, Yang Fei Tan, Yee Shan Wong, Melvin Wen Jie Liew, Subbu Venkatraman
https://iopscience.iop.org/article/10.1070/RCR4636/pdf
III. Factors affecting the delivery of nucleic acids by chitosan 232 IV. Non-covalent modification of chitosan 234 V. Covalent modification of chitosan 234 The review deals with the use of chitosan and its derivatives as vectors for delivery of nucleic acids in gene therapy. FactorsAuthor: Andrey S. Kritchenkov, Andrey S. Kritchenkov, Stanislav Andranovitš, Yury A. Skorik
https://www.intechopen.com/books/biological-activities-and-application-of-marine-polysaccharides/chitosan-chitosan-derivatives-and-their-biomedical-applications
Finally, the most recent advances in the biomedical applications of chitosan and its derivatives, especially tissue engineering, drug delivery systems, gene therapy systems and wound healing will be discussed.Author: Gustavo Adolfo Muñoz Ruiz, Hector Fabio Zuluaga Corrales
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