Chaperones And Intracellular Iron Delivery

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Coming into View: Eukaryotic Iron Chaperones and ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340153/
    Apr 20, 2012 · Poly(rC)-binding proteins can act as iron chaperones, delivering iron to target non-heme enzymes through direct protein-protein interactions. Although the molecular details have yet to be explored, these proteins, acting independently or together, may represent the basic cellular machinery for intracellular iron delivery.Author: Caroline C. Philpott

Coming into View: Eukaryotic Iron Chaperones and ...

    http://www.jbc.org/content/287/17/13518.full
    Apr 20, 2012 · In yeast cells, cytosolic monothiol glutaredoxins are required for the formation of heme and iron-sulfur clusters and the metallation of some non-heme iron enzymes. Poly (rC)-binding proteins can act as iron chaperones, delivering iron to target non …

Coming into View: Eukaryotic Iron Chaperones and ...

    https://www.researchgate.net/publication/221887227_Coming_into_View_Eukaryotic_Iron_Chaperones_and_Intracellular_Iron_Delivery_FIGURE_1
    Poly(rC)-binding proteins can act as iron chaperones, delivering iron to target non-heme enzymes through direct protein-protein interactions. Although the molecular details have yet to be explored,...

Intracellular copper routing: the role of copper chaperones

    https://www.sciencedirect.com/science/article/pii/S0968000499014929
    A recently discovered facet of homeostatic mechanisms is the protein-mediated, intracellular delivery of copper to target proteins. This routing is accomplished by a novel class of proteins, the ‘copper chaperones’.Author: Mark D Harrison, Christopher E Jones, Marc Solioz, Charles T Dameron

Intracellular copper routing: the role of copper chaperones

    https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(99)01492-9
    A recently discovered facet of homeostatic mechanisms is the protein-mediated, intracellular delivery of copper to target proteins. This routing is accomplished by a novel class of proteins, the ‘copper chaperones’.Author: Mark D Harrison, Christopher E Jones, Marc Solioz, Charles T Dameron

Frontiers Special delivery: distributing iron in the ...

    https://www.frontiersin.org/articles/10.3389/fphar.2014.00173/full
    Jul 22, 2014 · The loss of FIH1 activity and the physical interaction between cellular PCBP1 and FIH1 suggest that FIH1 is also a target for iron delivery by PCBP1. Whether all iron- and 2-OG-dependent enzymes require PCBPs for their metallation and activation remains undetermined. Other classes of iron metalloenzymes may also depend on iron delivery by PCBPs.Author: Caroline C. Philpott, Moon Suhn Ryu

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