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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1576229/
Aug 29, 2005 · Cell-penetrating peptides such as antennapedia, TAT, transportan and polyarginine have been extensively employed for in vitro and in vivo delivery of biologically active peptides. However, little is known of the relative efficacy, toxicity and uptake mechanism of individual protein transduction domain–peptide conjugates, factors that will be critical in determining the most effective sequence.Author: Simon W Jones, Richard Christison, Ken Bundell, Catherine J Voyce, Sarah M V Brockbank, Peter Newham...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179050/
Sep 20, 2011 · Delivery of macromolecules into cells and tissues such as skin is a major challenge. This obstacle poses a particular challenge for the delivery of siRNA where cellular and tissue level transport barriers need to be overcome. siRNAs are potential therapeutics ...Author: Tracy Hsu, Samir Mitragotri
https://www.cell.com/trends/pharmacological-sciences/fulltext/S0165-6147(19)30186-5
Self-assembly of designed synthetic peptides is a versatile strategy to generate functional materials for many applications. Given the biological relevance of their amino acid composition, one logical application for this class of materials lies in drug and therapeutic delivery. Peptide design alters the ultimate device form factor, ranging from circulating nanostructures to locally applied ...Author: Matthew J. Sis, Matthew J. Webber
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(16)30083-X
Jan 01, 2012 · Since then many demonstrations of antisense and siRNA cell delivery by CPPs have been published. Tables 1–4 show some recent examples. The choice of antisense mechanism or siRNA is dependent on the particular application and this in turn influences the type of …Author: Peter Järver, Thibault Coursindel, Samir El Andaloussi, Samir El Andaloussi, Caroline Godfrey, Matth...
https://www.nature.com/articles/nchem.2779
May 22, 2017 · The trapping of antibodies in endosomes often limits their use for intracellular targeting. Now, a single amino acid substitution on a spider-venom peptide has been shown to attenuate the cell ...Author: Misao Akishiba, Toshihide Takeuchi, Yoshimasa Kawaguchi, Kentarou Sakamoto, Hao-Hsin Yu, Ikuhiko Nak...
https://www.sciencedirect.com/science/article/pii/S0142961219307562
Direct nose-to-brain (N-to-B) delivery enables the rapid transport of drugs to the brain, while minimizing systemic exposure. The objective of this work was to engineer a nanocarrier intended to enhance N-to-B delivery of RNA and to explore its potential utility for the treatment of neurological disorders.Author: Eleni Samaridou, Hannah Walgrave, Evgenia Salta, David Moreira Álvarez, Vanessa Castro-López, Mabel ...
https://www.sciencedirect.com/science/article/pii/S1471489206001251
Peptide delivery. The use of peptide sequences that possess protein-specific biological activity, instead of full-length proteins, has numerous advantages in various cellular applications. Several functional studies have been carried out with these peptides when conjugated to CPPs and delivered into mammalian cells.Author: Maarja Mäe, Ülo Langel
https://pubs.acs.org/doi/10.1021/acs.bioconjchem.9b00877
Recently, development of techniques to deliver pharmacologically active biomacromolecules such as peptides and proteins to cytosol has gained much interest. Here, we applied the peptide gemini (PG)-surfactants to a novel platform to design cell penetration lipopeptides (CP-PGs), which can deliver exogenous peptides and proteins to cytosol. Among the number of candidate CP-PGs having different ...Author: Natsumi Sumito, Shuhei Koeda, Naoki Umezawa, Yasumichi Inoue, Shinya Tsukiji, Tsunehiko Higuchi, Tos...
https://www.researchgate.net/publication/338148636_SPA_a_peptide_antagonist_that_acts_as_a_cell-penetrating_peptide_for_drug_delivery
Although cell-penetrating peptides (CPPs) has been proven to be efficient transporter for drug delivery, ideal peptide vectors for tumor therapy are still being urgently sought.
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