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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583925/
Jan 01, 2013 · Cell type-specific gene delivery, which restricts gene transfer to therapy-relevant cells, hence reducing unwanted side effects caused by the ectopic expression of transgenes by off-target cells, remains one of the biggest challenges to improve the safety and efficacy of gene therapy.Author: Qi Zhou, Christian J. Buchholz
https://www.nature.com/articles/3301043
Jan 05, 2000 · Cell type-specific gene delivery will be essential for in vivo gene therapy. Our laboratory has previously developed retroviral vector particles, derived from spleen necrosis virus, SNV, which display the antigen-binding site of an antibody on the viral surface.Author: A Jiang, R Dornburg
https://www.sciencedirect.com/science/article/pii/S0042682203004021
Cell-type-specific gene delivery into neurons may present quite specific gene therapy approaches for many degenerative diseases of the brain. Previous article in issue Next article in issueAuthor: Zahida Parveen, Muhammad Mukhtar, Mohammed Rafi, David A Wenger, Khwaja M Siddiqui, Catherine A Sile...
https://www.sciencedaily.com/releases/2008/06/080623092534.htm
Jun 24, 2008 · Currently, a number of gene delivery systems for use on the arterial wall are being studied, but as yet their low efficiency in gene transfer and lack of cell-specific targeting and expression are major limitations. According to Dr. David Dean, …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726570/
By contrast, the SV40 DTS that acts in all cell types to promote DNA nuclear uptake, causes gene delivery and expression in multiple cell types throughout the lung, including type I and type II alveolar epithelial cells, airway epithelial cells, vascular and airway smooth muscle cells, fibroblasts, and endothelial cells.Author: David A. Dean
https://www.nature.com/articles/s41598-019-38533-7
Feb 07, 2019 · Recombinant baculoviruses function as gene delivery agents in mammalian cells. Their advantages include 1) the inability to replicate in mammalian cells, 2) apparent lack of cytotoxicity, 3) the capacity to sustain many inserted foreign DNAs, and 4) safer features than mammalian virus-based transduction systems 28.Author: Eun Byul Lee, Jung-Hee Kim, Wonhee Hur, Jung Eun Choi, Sung Min Kim, Dong Jun Park, Byung-Yoon Kang,...
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