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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043981/
Oct 30, 2010 · The Development of Cell-Specific Aptamers for Targeted Delivery. Cell-type-specific aptamers targeting cell surface biomarkers or receptors have been used for targeted delivery of various entities (Table 1 and Fig. 1). Decoration of DNA or RNA aptamers on delivery vehicles confers selectivity in cell type interactions and can result in cellular ...Author: Jiehua Zhou, John J. Rossi
https://www.ncbi.nlm.nih.gov/pubmed/32052583
Feb 13, 2020 · Cell-specific drug delivery remains a major unmet challenge for cancer nanomedicines. Here, light-triggered, cell-specific delivery of liposome-encapsulated doxorubicin to xenograft human cancer cells in live zebrafish embryos is demonstrated. This method relies on light-triggered dePEGylation of liposome surfaces to reveal underlying targeting ...Author: Li Kong, Quanchi Chen, Frederick Campbell, Ewa Snaar‐Jagalska, Alexander Kros
https://www.thno.org/v05p0863.htm
For the EVs and cell membrane coated NPs, the retention of the membrane proteins and nano-size structure make them more feasible to achieve site-specific drug delivery than whole cell as drug carrier.
https://pubs.acs.org/doi/abs/10.1021/nn405724x
Advances in genetic engineering tools have contributed to the development of strategies for utilizing biologically derived vesicles as nanomedicines for achieving cell-specific drug delivery. Here, we describe bioengineered bacterial outer membrane vesicles (OMVs) with low immunogenicity that can target and kill cancer cells in a cell-specific manner by delivering small interfering RNA (siRNA ...Author: Vipul B Gujrati, Sung Hyun Kim, Sang-Hyun Kim, Jung Joon Min, Hyon E. Choy, Sun-Chang Kim, Sangyong ...
https://www.nature.com/articles/ncomms13580
Nov 24, 2016 · Delivery of siRNA to target cells is essential for in vivogene therapy. Here the authors demonstrate an oligonucleotide aptamer that targets therapeutic siRNA to a specific cell type.Author: Kewei Ren, Ying Liu, Jie Wu, Yue Zhang, Jing Zhu, Min Yang, Huangxian Ju
https://www.onlinelibrary.wiley.com/doi/pdf/10.1002/anie.200901452
Aug 12, 2009 · Aptamer advantages: Cell‐specific delivery of the anticancer drug cisplatin through a nucleolin‐aptamer‐conjugated, cisplatin‐encapsulating liposome delivery system is described. Calcein was incorporated into the target MCF‐7 cells (see top image) but …Author: Zehui Cao, Rong Tong, Abhijit Mishra, Weichen Xu, Gerard C. L. Wong, Jianjun Cheng, Yi Lu
https://www.nibib.nih.gov/science-education/science-topics/drug-delivery-systems-getting-drugs-their-targets-controlled-manner
Drug delivery systems are engineered technologies for the targeted delivery and/or controlled release of therapeutic agents. Drugs have long been used to improve health and extend lives. The practice of drug delivery has changed dramatically in the past few decades and even greater changes are …
https://www.sciencedirect.com/science/article/pii/S0169409X07002505
Drug delivery has been greatly improved over the years by means of chemical and physical agents that increase bioavailability, improve pharmacokinetic and reduce toxicities. At the same time, cell based delivery systems have also been developed.Author: F. Pierigè, S. Serafini, L. Rossi, M. Magnani
https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.201901489
Cell‐specific drug delivery remains a major unmet challenge for cancer nanomedicines. Here, light‐triggered, cell‐specific delivery of liposome‐encapsulated doxorubicin to xenograft human cancer cells in live zebrafish embryos is demonstrated.Author: Li Kong, Quanchi Chen, Frederick Campbell, Ewa Snaar‐Jagalska, Alexander Kros
https://www.nature.com/articles/s41392-017-0004-3
Mar 16, 2018 · Furthermore, specific drug delivery can be achieved via active targeting by the functionalizing of MSNs with targeting ligands, such as folate …Author: Sudipta Senapati, Arun Kumar Mahanta, Sunil Kumar, Pralay Maiti
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