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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128881/
In our previous studies, we have reported the development of novel cardiomyocyte-targeting bioreducible polymers for siRNA delivery to the myocardium [1, 6]. In these studies, our primary cardiomyocyte targeting peptide (PCM) conjugated bioreducible polymer targeted siRNA delivery to cardiomyocytes with higher transfection efficiency.Author: Hye Yeong Nam, Jaesung Kim, Soojin Kim, James W. Yockman, Sung Wan Kim, David A. Bull
https://www.sciencedirect.com/science/article/pii/S0142961211003565
Cell-penetrating peptides (CPP)s, such as the Tat peptide, have been used extensively in vitro and in vivo to facilitate the uptake of a range of biological chemicals. For enhanced penetration with targeting, the Tat peptide was introduced to the cardiomyocyte-targeting PCM-modified polymer.Author: Hye Yeong Nam, Jaesung Kim, Soojin Kim, James W. Yockman, Sung Wan Kim, David A. Bull
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)36733-8
For more enhanced transfection efficiency with targeting, we designed and synthesized new bioreducible polymer conjugated with both PCM peptide and Tat peptide. Tat sequence which is a cell penetrating peptide (CPP) known as key player for the cellular uptake of HIV-1 Tat peptide, was introduced to the PCM-CD to enhance the cellular uptake of ...
https://www.researchgate.net/publication/51059636_Cell_Penetrating_Peptide_Conjugated_Bioreducible_Polymer_for_siRNA_Delivery
Regarding siRNA delivery, a novel approach was proposed by Nam et al., who used the Tat peptide to enhance the delivery of a siRNA-loaded bioreducible polymer targeted to cardiomyocytes [130]. In ...
http://europepmc.org/articles/PMC3128881
Cell Penetrating Peptide Conjugated Bioreducible Polymer for siRNA Delivery Hye Yeong Nam , a Jaesung Kim , a Soojin Kim , b James W. Yockman , a Sung Wan Kim , a and David A. Bull c, * a Center for Controlled Chemical Delivery (CCCD), Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112
https://www.sciencedirect.com/science/article/pii/S0006291X14001429
Cell-penetrating peptide-conjugated lipid nanoparticles for siRNA delivery. ... were designed for siRNA delivery. ... Y. Takashima, H. OkadaSuppression of tumor growth by systemic delivery of anti-VEGF siRNA with cell-penetrating peptide-modified MPEG-PCL nanomicelles. Eur. J. Pharm. Biopharm., 81 (2012), pp. 470-477. Google Scholar.Author: Tomohiro Asai, Takuma Tsuzuku, Shoya Takahashi, Ayaka Okamoto, Takehisa Dewa, Mamoru Nango, Kenji Hy...
https://www.deepdyve.com/lp/elsevier/cell-penetrating-peptide-conjugated-bioreducible-polymer-for-sirna-iN5PzL5ERM
Aug 01, 2011 · Read "Cell penetrating peptide conjugated bioreducible polymer for siRNA delivery, Biomaterials" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
http://europepmc.org/abstract/MED/21501867
Sep 01, 2011 · The primary cardiomyocyte-specific peptide (PCM) and the cell-penetrating peptide (CPP), HIV-Tat (49-57), were incorporated into the polymer, cystamine bisacrylamide-diaminohexane (CBA-DAH), to increase the delivery of RNAi to target cells, specifically cardiomyocytes.
https://www.cell.com/molecular-therapy-family/molecular-therapy/pdf/S1525-0016(16)31480-0.pdf
and biodistribution. Cell-penetrating peptides (CPPs) have been shown to improve the intracellular delivery of various biologically active molecules into living cells and have more recently been applied to siRNA delivery. To improve cellular uptake of siRNA into challenging cell lines, we have designed a secondary amphipathic peptide
https://pubs.acs.org/doi/abs/10.1021/mp200589z
To deliver siRNA specifically to cardiomyocytes with a high transfection efficiency, primary cardiomyocyte-targeting (PCM) and/or cell-penetrating (Tat) peptides were incorporated into the siRNA. With the addition of plasmid DNA, these peptide-conjugated siRNAs were able to form compact and stable nanosized polyplex particles with bioreducible poly(CBA-DAH). The peptide-modified siRNA ...Author: Hye Yeong Nam, Jaesung Kim, Sung Wan Kim, David A. Bull
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