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https://www.sciencedirect.com/science/article/pii/B9780124160200000140
Cell delivery of drug nanoparticles has been demonstrated for animal models of disease. However, these methods have not yet been tested in a clinical setting. For clinical use, cell carriers could be harvested from the patient's blood by apharesis, loaded with drug, and then readministered to the patient.Author: JoEllyn M McMillan, Elena Batrakova, Howard Eliot Gendelman
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016803/
Cell Delivery of Therapeutic Nanoparticles. ... Cell delivery of drug nanoparticles has been demonstrated for animal models of disease. However, these methods have not yet been tested in a clinical setting. For clinical use, cell carriers could be harvested from the patient’s blood by apharesis, loaded with drug, and then readministered to ...Author: JoEllyn M McMillan, Elena Batrakova, Howard Eliot Gendelman
https://www.ncbi.nlm.nih.gov/pubmed/22093229
Cell delivery of therapeutic nanoparticles. McMillan J(1), Batrakova E, Gendelman HE. Author information: (1)Department of Pharmacology and Experimental Neuroscience, Nebraska Medical Center, Omaha, NE, USA.Author: JoEllyn M McMillan, Elena Batrakova, Howard Eliot Gendelman
https://www.researchgate.net/publication/51810001_Cell_Delivery_of_Therapeutic_Nanoparticles
Cell Delivery of Therapeutic Nanoparticles. ... As reported in several review articles, cell-mediated drug delivery has emerged to overcome these obstacles and to serve as an alternative for the ...
http://pubs.acs.org/doi/abs/10.1021/nl072209h
Destruction of hypoxic regions within tumors, virtually inaccessible to cancer therapies, may well prevent malignant progression. The tumor's recruitment of monocytes into these regions may be exploited for nanoparticle-based delivery. Monocytes containing therapeutic nanoparticles could serve as “Trojan Horses” for nanoparticle transport into these tumor regions.
https://clincancerres.aacrjournals.org/content/14/5/1310
Mar 01, 2008 · Cancer nanotherapeutics are rapidly progressing and are being implemented to solve several limitations of conventional drug delivery systems such as nonspecific biodistribution and targeting, lack of water solubility, poor oral bioavailability, and low therapeutic indices. To improve the biodistribution of cancer drugs, nanoparticles have been designed for optimal size and surface ...Author: Kwangjae Cho, Kwangjae Cho, Xu Wang, Shuming Nie, Zhuo (Georgia) Chen, Dong M. Shin
http://europepmc.org/abstract/MED/22093229
Jan 01, 2011 · Cell Delivery of Therapeutic Nanoparticles. ... Cell delivery of drug nanoparticles has been demonstrated for animal models of disease. However, these methods have not yet been tested in a clinical setting. For clinical use, cell carriers could be harvested from the patient’s blood by apharesis, loaded with drug, and then readministered to ...Author: JoEllyn M McMillan, Elena Batrakova, Howard Eliot Gendelman
https://www.cell.com/molecular-therapy-family/methods/fulltext/S2329-0501(16)30165-6
Jan 01, 2016 · Gene therapy is a promising strategy for specific treatment of numerous gene-associated human diseases by intentionally altering the gene expression in pathological cells. A successful clinical application of gene-based therapy depends on an efficient gene delivery system. Many efforts have been attempted to improve the safety and efficiency of gene-based therapies. Nanoparticles have been ...Author: Jie Chen, Zhaopei Guo, Huayu Tian, Xuesi Chen
https://www.sciencedirect.com/science/article/abs/pii/S0168365915300328
In particular, cell membrane-camouflaged nanoparticles are a new class of biomimetic nanoparticles that combine the unique functionalities of cellular membranes and engineering versatility of synthetic nanomaterials for effective delivery of therapeutic agents.Author: Brian T. Luk, Liangfang Zhang
https://www.nih.gov/news-events/nih-research-matters/therapeutic-nanoparticles-grapefruit-juice
Therapeutic Nanoparticles from Grapefruit Juice ... Nanoparticles are emerging as an efficient tool for drug delivery. Microscopic pouches made of synthetic lipids can serve as a carrier, or vector, to protect drug molecules within the body and deliver them to specific cells. ... scientists have found that mammalian exosomes — tiny lipid ...
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