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https://www.ncbi.nlm.nih.gov/pubmed/21736956
There is a growing interest in the clinical application of stem cells as a novel therapeutic approach for treatment of myocardial infarction and prevention of subsequent heart failure. Transplanted stem cells improve cardiac functions through multiple mechanisms, which include but are not limited to promoting angiogenesis, replacing dead cardiomyocytes, modulating cardiac remodeling.Author: Kai Hong Wu, Kai Hong Wu, Zhong Chao Han, Xu Ming Mo, Bin Zhou
https://www.sciencedirect.com/science/article/pii/S1568163711000493
Stem cell delivery strategies in cardiac regenerative therapy. A: Intravenous infusion; B: open chest direct myocardial injection or surgical injection of engineered stem cells; C: catheter based intracoronary artery infusion, intracoronary venous infusion, and catheter-based direct myocardial injection; D: engineered myocardial patch or cell sheet transplantation.Author: Kai Hong Wu, Kai Hong Wu, Zhong Chao Han, Xu Ming Mo, Bin Zhou
https://www.researchgate.net/publication/51474756_Cell_delivery_in_cardiac_regenerative_therapy
Cardiac cell therapy for regenerative purposes has been clinically applied in the fields of cardiac surgery and interventional cardiology for almost one decade.
https://www.nature.com/articles/s41569-018-0013-0
May 09, 2018 · Abstract. The effects of cell therapy on heart regeneration in patients with chronic cardiomyopathy have been assessed in several clinical trials. These trials can be categorized as those using noncardiac stem cells, including mesenchymal stem cells, and those using cardiac-committed cells, including KIT + cardiac stem cells,...Author: Philippe Menasché
https://www.sciencedirect.com/science/article/pii/S0169409X1400180X
This review encompasses drug and cell delivery for cardiac regeneration. This treatment can be cardioprotective; to protect heart muscle tissue after an acute myocardial infarction (MI), or cardiorestorative; to regenerate tissue in patients with chronic ischaemic heart failure.Author: Conn L. Hastings, Conn L. Hastings, Ellen T. Roche, Ellen T. Roche, Eduardo Ruiz-Hernandez, Eduardo ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241533/
The next cells used for cardiac regeneration therapy were unselected bone marrow-derived mononuclear cells, which became widely tested in clinical studies for heart disease 37. This approach was supported by studies demonstrating a beneficial contribution of bone marrow-derived mononuclear cells to cardiac repair in animal models after acute MI 38 , 39 .Author: Hisayuki Hashimoto, Eric N. Olson, Rhonda Bassel-Duby
https://www.mayo.edu/research/centers-programs/center-regenerative-medicine/focus-areas/cardiac-regeneration
Stem cell therapy is already a treatment option for patients with advanced heart failure due to heart attack. Now, new discoveries are underway to improve stem cells' regenerative therapeutic impact for many patients in need.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899023/
May 25, 2016 · The direct injection of cells into the ventricular wall is considered as a favored method for cell delivery when an occluded coronary artery precludes transvascular cell delivery or when cell homing signals are expressed at low levels in the heart.Author: Rongrong Sun, Xianchi Li, Min Liu, Yi Zeng, Shuang Chen, Peying Zhang
https://www.nature.com/articles/s41536-017-0024-1
Jun 13, 2017 · Evolution of translational cardiac regenerative therapies. First-generation cell types such as SMs, BMMNCs, HSCs, EPCs, and MSCs demonstrated feasibility and safety with, however, heterogeneous outcomes and limited efficacy in the clinical setting.
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