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https://www.sciencedirect.com/science/article/pii/S0169409X00000557
Some of the numerous disorders associated with a dysfunctional central nervous system (CNS) include Alzheimer’s disease (AD) and other dementias, cerebrovascular disease (associated with stroke), epilepsy, Parkinson’s disease (PD), multiple sclerosis (MS), spinal cord injury (SCI), dystonias, dysfunctions associated with head trauma and cancer, and psychiatric disorders.Author: Molly S Shoichet, Shelley R Winn
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642746/
Successful use of cell-based therapies for the treatment of neurological diseases is dependent upon effective delivery to the central nervous system (CNS). The CNS poses several challenges to the delivery of cell-based therapeutics, including the blood–brain …Author: Matthew B. Potts, Matthew T. Silvestrini, Daniel A. Lim
https://www.researchgate.net/publication/12377588_Cell_delivery_to_the_central_nervous_system
The blood-brain barrier (BBB) is a highly efficient system that separates the central nervous system (CNS) from general circulation and promotes selective transport of molecules that are essential ...
https://scopeblog.stanford.edu/2020/04/08/gel-smooths-cells-ride-through-syringes-in-regenerative-therapy/
3 days ago · Nerve cells in the peripheral nervous system can regenerate after being severely injured. Nerves in the central nervous system -- the brain and spinal cord -- can't. No cell-based regenerative therapies have proved successful in reversing spinal-cord damage. The cells used in the Stanford Medicine study were Schwann cells.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684241/
An effective, efficient delivery system must do all three: provide a molecular address to the agent for delivery to neuronal cells, gain access to the brain by crossing the BBB and protect the agent from serum degradation en route. Using siRNA as a therapeutic agent and prion diseases as models, we have developed three therapeutic delivery systems that address all of these issues.
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