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https://www.sciencedirect.com/science/article/pii/S0378517310002218
Physicochemical properties of cationic liposomes were investigated. A GFP siRNA was used as a model siRNA to test the efficiency of cationic liposome-mediated siRNA delivery. The liposomes could enhance delivery efficiency and decrease cytotoxicity at an optimized lipid composition.Author: Hyun-Ki Kim, Enkhzaya Davaa, Chang-Seon Myung, Jeong-Sook Park
https://www.researchgate.net/publication/279760183_Cationic_surfactin_liposomes_for_enhanced_cellular_delivery_of_siRNA
When compared with surfactin-free liposomes, cationic surfactin liposomes showed enhanced cellular delivery of siRNA in Hela cells. More than 85% of the cells were positive for siRNA and following its delivery 14% of surfactin-containing liposomes.
https://www.sciencedirect.com/science/article/pii/S181808761300010X
A number of researchers have sought to enhance the cellular delivery and gene-silencing efficiencies of siRNA using cationic liposomes. For example, cationic liposomes composed of DC-6-14, DOPE, and cholesterol were formulated to deliver siRNAs specific for firefly luciferase [35] .Author: Gayong Shim, Mi-Gyeong Kim, Joo Yeon Park, Yu-Kyoung Oh
https://www.sciencedirect.com/science/article/pii/S1773224718307408
With this background present study is designed to deliver combination of chemotherapeutic drug and anticancer siRNA through cationic liposomes (CLs) to achieve enhanced efficacy in breast cancer. Paclitaxel (PTX) is the first-line drug against breast and ovarian cancers [ 9 ].Author: Upendra Bulbake, Nagavendra Kommineni, Maria Bryszewska, Maksim Ionov, Wahid Khan
https://www.sciencedirect.com/science/article/pii/S037851730700960X
Therefore, in this study, we focused on development of new cationic lipid-based delivery systems of siRNA that can increase serum stability and transfection efficiency. Here, we report that a newly synthesized cholesterol-derivative might be useful for enhanced cellular delivery of siRNA via liposomes in a serum-stable manner. 2. Material and ...Author: Su-Eun Han, Hyungu Kang, Ga Yong Shim, Min Sung Suh, Sun Jae Kim, Jin-Seok Kim, Yu-Kyoung Oh
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)30655-4
Apr 01, 2013 · Here, we report a cationic nanolipoplex as a pulmonary cellular delivery system for small-interfering RNA (siRNA). Six nanoliposomes differing in cationic lipids were formulated and screened in vitro and in vivo for cellular delivery functions in lung cells/tissues. Although the six nanoliposomes showed similar siRNA delivery efficiency in vitro, they exhibited significant …Author: Gayong Shim, Hyun Woo Choi, Sangbin Lee, Junhyeok Choi, Yong Hee Yu, Da Eui Park, Yongseok Choi, Cha...
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