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https://www.sciencedirect.com/science/article/pii/S0168365918301202
The clinical success of chimeric antigen receptor (CAR) T cell immunotherapy in treating multiple blood cancers has created a need for efficient methods of ex vivo gene delivery to primary human T cells for cell engineering. Here, we synthesize and evaluate a panel of cationic polymers for gene delivery to both cultured and primary human T cells.Author: Brynn R. Olden, Yilong Cheng, Jonathan L. Yu, Suzie H. Pun
https://www.ingentaconnect.com/content/ben/mrmc/2010/00000010/00000002/art00002
Therefore, optimization of cationic polymers is necessary to improve the gene transfection efficiency. Currently several important cationic polymers were used as cationic vectors for gene delivery which included PEI, PLL, Chitosan and PAMAM. Their most advantages and …
http://www.eurekaselect.com/86136/article
Keywords:Cationic polymer, polyplexes, gene delivery, optimization. Abstract: The polyplexes which are formed between cationic polymers and DNA through electrostatic interactions and thus known as polycation/DNA complexes, are by far the most widely used non-viral gene delivery vectors. Many factors such as molecular weight, surface charge ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051313/
Background. Cationic liposome (CL)-DNA complexes are promising gene delivery vectors with potential applications in gene therapy. A key challenge in creating CL-DNA complexes for applications is that their transfection efficiency (TE) is adversely affected by serum.Author: Chia Ling Chan, Chia Ling Chan, Kai K. Ewert, Ramsey N. Majzoub, Yeu Kuang Hwu, Keng S. Liang, Cecíl...
https://link.springer.com/article/10.1023%2FA%3A1007548826495
Feb 01, 2000 · Gene transfer to humans requires carriers for the plasmid DNA which canefficiently and safely carrythe gene into the nucleus of the desired cells. A series of chemically differentcationic polymers arecurrently being investigated for these purposes. Although many cationic polymersindeed condense DNAspontaneously, which is a requirement for gene transfer in most types of cells,the ...Author: Stefaan C. De Smedt, Joseph Demeester, Wim E. Hennink
https://www.researchgate.net/publication/261719603_Optimizing_Cationic_and_Neutral_Lipids_for_Efficient_Gene_Delivery_at_High_Serum_Content
Optimizing Cationic and Neutral Lipids for Efficient Gene Delivery at High Serum Content Article in The Journal of Gene Medicine 16(3-4) · March 2014 with 56 Reads How we measure 'reads'
https://www.sciencedirect.com/science/article/pii/S0141813017329112
Synthesis and characterization of bioreducible cationic biarm polymer for efficient gene delivery Author links open overlay panel Yugyeong Kim a 1 Saji Uthaman a 1 Md Nurunnabi a 1 2 Sudipta Mallick a Keun Sang Oh a Sun-Woong Kang b Sungpil Cho c Han Chang Kang d Yong-kyu Lee e Kang Moo Huh aAuthor: Yugyeong Kim, Saji Uthaman, Nurunnabi, Sudipta Mallick, Keun Sang Oh, Sun-Woong Kang, Sungpil Cho, H...
https://www.pnas.org/content/pnas/95/4/1517.full.pdf
ciencies of gene transfer vary with these systems, a large variety of cationic structures are effective. Unfortunately, it has been difficult to study systematically the effect of polycation struc-ture on transfection activity. To understand more fully the structure–activity relationship of these cationic polymer delivery systems, we examined ...Author: John E. Murphy, Tetsuo Uno, Janice D. Hamer, Fred E. Cohen, Varavani Dwarki, Ronald N. Zuckermann
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294582/
Chitosan, a naturally occurring cationic polysaccharide is an attractive candidate for gene delivery because of its several advantages, such as biocompatibility, biodegradability and low toxicity [63, 64]. Mumper et al. introduced chitosan as a non-viral vector for gene delivery. The primary amine groups of chitosan can readily form complexes ...Author: Sutapa Barua, James Ramos, Thrimoorthy Potta, David Taylor, Huang Chiao Huang, Gabriela Montanez, Ka...
https://www.researchgate.net/publication/6713116_Optimization_of_25_kDa_linear_polyethylenimine_for_efficient_gene_delivery
In the last few years, linear polyethylenimine (LPEI) emerged as an attractive cationic polymer for efficient gene delivery in vitro and in vivo due to its negligible cytotoxicity 7 8. Recently ...
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