We have collected information about Cationic Polymer Optimization Efficient Gene Delivery for you. Follow the links to find out details on Cationic Polymer Optimization Efficient Gene Delivery.
http://www.eurekaselect.com/86136/article
Many factors such as molecular weight, surface charge, charge density, hydrophilicity and the structure of cationic polymers affect gene transfection efficiency of cationic polymers. Therefore, optimization of cationic polymers is necessary to improve the gene transfection efficiency. Currently several important cationic polymers were used as cationic vectors for gene delivery which included PEI, PLL, Chitosan …
https://www.ingentaconnect.com/content/ben/mrmc/2010/00000010/00000002/art00002
Therefore, optimization of cationic polymers is necessary to improve the gene transfection efficiency. Currently several important cationic polymers were used as cationic vectors for gene delivery which included PEI, PLL, Chitosan and PAMAM. Their most advantages and the rational design are introduced in this article. However, these systems are much less efficient in gene transfer experiments …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051313/
Cationic liposome (CL)-DNA complexes are promising gene delivery vectors with potential applications in gene therapy. A key challenge in creating CL-DNA complexes for applications is that their transfection efficiency (TE) is adversely affected by serum.Author: Chia Ling Chan, Chia Ling Chan, Kai K. Ewert, Ramsey N. Majzoub, Yeu Kuang Hwu, Keng S. Liang, Cecíl...
https://www.sciencedirect.com/science/article/pii/S0168365918301202
Polymers for gene delivery are typically made of cationic monomers that contain primary, secondary, and/or tertiary amine groups that can complex with negatively charged nucleic acid to form condensed polymer-nucleic acid nanoparticle complexes, called “polyplexes” .Author: Brynn R. Olden, Yilong Cheng, Jonathan L. Yu, Suzie H. Pun
https://link.springer.com/article/10.1023%2FA%3A1007548826495
Feb 01, 2000 · Although many cationic polymersindeed condense DNAspontaneously, which is a requirement for gene transfer in most types of cells,the physicochemical andbiopharmaceutical behavior of the current generation of polyplexes severelylimits an efficient genetransfer in vitro and especially in vivo. This papersummarizes recent physicochemical and biologicalinformation on polyplexes and aims to provide new insights with respect to thistype of gene deliverysystem.Author: Stefaan C. De Smedt, Joseph Demeester, Wim E. Hennink
https://onlinelibrary.wiley.com/doi/abs/10.1002/marc.201800068
Cationic Polymer‐Mediated CRISPR/Cas9 Plasmid Delivery for Genome Editing Zhen Zhang Key Laboratory of Gene Engineering of the Ministry of Education, Guangzhou Key Laboratory of Healthy Aging Research and State Key Laboratory of Biocontrol, SYSU‐BCM Joint Research Center, School of Life Sciences, Sun Yat‐sen University, Guangzhou, 510275 ...Author: Zhen Zhang, Tao Wan, Tao Wan, Yuxuan Chen, Yu Chen, Hongwei Sun, Tianqi Cao, Zhou Songyang, Guping T...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294582/
Polymers are synthetic gene delivery vectors which possess the ability to deliver genetic material to target cells [3, 4, 12, 13]. Cationic polymers neutralize the negative charge on plasmid DNA resulting in the formation of nanoscale polymer-DNA complexes (polyplexes).Author: Sutapa Barua, James Ramos, Thrimoorthy Potta, David Taylor, Huang Chiao Huang, Gabriela Montanez, Ka...
https://www.sciencedirect.com/science/article/pii/S0141813017329112
Bioreducible and non-bioreducible miktoarm block copolymers (mPEG- (ss-PLL) 2 and mPEG-PLL 2) were prepared for efficient gene delivery as a non-viral gene delivery approach. Both cationic copolymers (bioreducible and nonbioreducible) efficiently formed the …Author: Yugyeong Kim, Saji Uthaman, Nurunnabi, Sudipta Mallick, Keun Sang Oh, Sun-Woong Kang, Sungpil Cho, H...
https://www.researchgate.net/publication/6713116_Optimization_of_25_kDa_linear_polyethylenimine_for_efficient_gene_delivery
Toxic gene delivery is one of the most effective methods for cancer therapy. Cationic polymers are able to form stable nanoparticles via interaction with nucleic acids electrostatically.
https://www.pnas.org/content/pnas/95/4/1517.full.pdf
ciencies of gene transfer vary with these systems, a large variety of cationic structures are effective. Unfortunately, it has been difficult to study systematically the effect of polycation struc-ture on transfection activity. To understand more fully the structure–activity relationship of these cationic polymer delivery systems, we examined ...Author: John E. Murphy, Tetsuo Uno, Janice D. Hamer, Fred E. Cohen, Varavani Dwarki, Ronald N. Zuckermann
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