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https://www.sciencedirect.com/science/article/pii/S0927775718305880
Oct 20, 2018 · In our previous studies, the production of cationic liposomes (CLs) using an EPC/DOTAP/DOPE lipid formulation was investigated in order to evaluate the capacity of CLs as a vector system for plasmid DNA delivery [21,22,31]. In the present work, the complexation between EPC/DOTAP/DOPE-based liposomes with siRNA is characterized.Author: Ismail Eş, Meryem Tyrrasch Ok, Ximena E. Puentes-Martinez, Marcelo Augusto Szymanski de Toledo, Mari...
https://www.sciencedirect.com/science/article/pii/S181808761300010X
For example, Arg-Gly-Asp (RGD) peptide-modified liposomes were studied for their ability to enhance the delivery of nucleic acids to integrin receptor-expressing cells .RGD-modified cationic liposomes loaded with p-glycoprotein-specific siRNAs showed higher delivery to integrin receptor-expressing human breast cancer MCF7/A cells, resulting in significant silencing of p-glycoprotein.Author: Gayong Shim, Mi-Gyeong Kim, Joo Yeon Park, Yu-Kyoung Oh
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598202/
Oct 01, 2015 · For example, PEGylated liposomes were designed to co-encapsulate anti-bcr-abl siRNA and imatinib mesylate for chronic myeloid leukemia treatment.8 Dual-stimuli-sensitive micelles were used to co-deliver doxorubicin and bcl-2 siRNA.9 Quantum dots functionalized by β-cyclodextrin were designed for co-delivery of doxorubicin and mdr1 siRNA.10 ...Author: Yao Yao, Zhihui Su, Yanchao Liang, Na Zhang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052284/
Efficient non-viral delivery of siRNA requires stable formulation and targeting of lipoplexes to the growing tumors as well as specificity and functionality of the delivered siRNA cargo. Several recent reports have demonstrated the efficacy of DOTAP/DOPE cationic liposomes in delivering antisense oligonucleotides and siRNA to targeted tumors. 7 ...Author: M. Mikhaylova, I. Stasinopoulos, Y. Kato, Dmitri Artemov, Zaver M Bhujwalla
http://www.thno.org/v05p0583.htm
Abstract. For efficient delivery of small interfering RNA (siRNA) to the target diseased site in vivo, it is important to design suitable vehicles to control the blood circulation of siRNA.It has been shown that surface modification of cationic liposome/siRNA complexes (lipoplexes) with polyethylene glycol (PEG) could enhance the circulation time of lipoplexes.
https://www.thno.org/v05p0583.pdf
In this study, cationic liposomes based siRNA delivery system with the modification of PCB was developed. The performances of PCBylated lipoplexes in pharmacokinetics, biodistribution and tumor therapy were investigated. Our findings demon-strated that PCBylation could avoid ABC phenome-non, which facilitated the tumor accumulation and
https://www.mdpi.com/2079-4991/8/5/270
In recent year, cationic liposomes have gained a lot of attention for siRNA delivery. Despite this, intracellular barriers as endosomal escape and cytosolic delivery of siRNA still represent a challeng, as well as the cytotoxicity due to cationic lipids. To address these issues, we developed four liposomal formulations, composed of two different cationic lipids (DOTAP and DC-Cholesterol) and ...Author: Anna Lechanteur, Vincent Sanna, Amandine Duchemin, Brigitte Evrard, Denis Mottet, Géraldine Piel
http://pubs.acs.org/doi/abs/10.1021/la803973p
Short interfering RNA (siRNA) holds great potential for the treatment of hard-to-cure diseases. One of the major challenges to translate siRNA into drugs is its efficient delivery to its site-of-action, namely the cytoplasm of the target cells. Cationic liposomes have been shown to do the trick, but their short circulation lifetime and potential aggregation in blood limit their applicability ...
https://www.hindawi.com/journals/jphar/2013/149695/
We developed elastic cationic liposomal vectors for transdermal siRNA delivery. These liposomes were prepared with 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) as a cationic lipid and sodium cholate (NaChol) or Tween 80 as an edge activator. When NaChol or Tween 80 was included at 5, 10, and 15% (w/w) into DOTAP liposomal formulations (C5-, C10-, and C15-liposomes and T5-, T10-, and T15 ...Author: Yoshiyuki Hattori, Masataka Date, Shohei Arai, Kumi Kawano, Etsuo Yonemochi, Yoshie Maitani
https://onlinelibrary.wiley.com/doi/full/10.1111/dgd.12123
Cationic liposomes are also attractive non‐viral delivery systems. Liposomes form a complex with siRNA (siRNA‐lipoplex) and enhance the cellular uptake of siRNA through electrostatic interactions between lipoplexes and the plasma membrane of cells. Successful in vitro and in vivo gene silencing with lipoplexes has been reported (Spagnou et al.Author: Hiroyo Mori, Nobuhiko Kawai, Nao Kinouchi, Natsuko Hichijo, Tatsuhiro Ishida, Emi Kawakami, Sumihare...
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