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https://www.nature.com/articles/nbt.3081
Oct 30, 2014 · Efficient protein delivery using cationic lipid transfection reagents enables high efficiency protein-based genome editing in vivo and in vitro. Efficient intracellular delivery of proteins is ...Author: John A. Zuris, John A. Zuris, David B. Thompson, David B. Thompson, Yilai Shu, John P. Guilinger, Jo...
https://www.thermofisher.com/us/en/home/references/gibco-cell-culture-basics/transfection-basics/gene-delivery-technologies/cationic-lipid-mediated-delivery/how-cationic-lipid-mediated-transfection-works.html
Cationic lipid-mediated delivery is a fast, simple, and reproducible means for easily introducing DNA, RNA, siRNA, or oligonucleotides into eukaryotic cells. It allows the highly efficient transfection of a broad range of cell types, including adherent, suspension, and insect cells, as well as primary cultures.
https://www.ncbi.nlm.nih.gov/pubmed/25357182
Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo. ... Here we report that common cationic lipid nucleic acid transfection reagents can potently deliver proteins that are fused to negatively supercharged proteins, that contain natural anionic domains or that natively bind to anionic ...Author: John A. Zuris, John A. Zuris, David B. Thompson, David B. Thompson, Yilai Shu, John P. Guilinger, Jo...
http://arbutusbio.com/docs/Semple_et_al_2010.pdf
of mediating efficient delivery of siRNA in vitro and in vivo. Here, we instead used a medicinal chemistry (that is, structure-activity relation-ship) approach, guided by the putative in vivo mechanism of action of ionizable cationic lipids, for rational lipid design. Specifically, we …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867951/
However, the utility of RNAi is limited by the efficiency and toxicity of the available siRNA delivery vehicles. To improve cationic lipid-based vectors, it is important to gain a better understanding of the relationship between the chemical-physical parameters and the biological, gene silencing activity of cationic lipid–siRNA (CL–siRNA ...Author: Kai K. Ewert, Alexandra Zidovska, Alexandra Zidovska, Ayesha Ahmad, Nathan F. Bouxsein, Heather M. E...
https://www.sciencedirect.com/science/article/pii/S0142961219301504
DOTAP has been extensively utilized to formulate cationic liposomes for antigen delivery, which can enhance the antigen internalization and processing by DCs . In our study, the outer lipid layer of MAN-IMO-PS composed of DOTAP, MPLA and DSPE-PEG-Man, thus can function in different manner to enhance vaccine entry into DCs.Author: Dunwan Zhu, Chunyan Hu, Fan Fan, Yu Qin, Chenlu Huang, Zhiming Zhang, Lu Lu, Hai Wang, Hongfan Sun, ...
http://arbutusbio.com/docs/Protiva_Heyes_et_al_2005.pdf
Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids James Heyes 1, Lorne Palmer 1, Kaz Bremner, Ian MacLachlan* Protiva Biotherapeutics Inc., 100-3480 Gilmore Way, Burnaby, B.C., Canada V5G-4Y1
https://www.sciencedirect.com/science/article/pii/S0168365906003191
Cationic lipids, lipoplexes and intracellular delivery of genes. Author links open overlay panel ... Since insertion of the cationic lipid alone was ineffective, these data were taken to suggest that the cationic lipid/DOPE mixture destabilized the plasma membrane of cells, presumably relying on the ability of the mixture to adopt the hexagonal ...Author: Luc Wasungu, Dick Hoekstra
https://patents.google.com/patent/US9567296B2/en
US9567296B2 US14/707,796 US201514707796A US9567296B2 US 9567296 B2 US9567296 B2 US 9567296B2 US 201514707796 A US201514707796 A US 201514707796A US 9567296 B2 US9567296 B2 US 9567296B2 Authority US United States Prior art keywords mol lipid compound atx rna Prior art date 2013-11-18 Legal status (The legal status is an assumption and is not a legal conclusion.Author: Joseph E. Payne, Padmanabh Chivukula
https://www.researchgate.net/publication/234086701_Nonviral_Cationic_Lipid-Mediated_Delivery_of_mRNA
Appropriate gene delivery systems are essential for successful gene therapy in clinical medicine. Cationic lipid-mediated delivery is an alternative to viral vector-mediated gene delivery where ...
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