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http://www.pathwaymedicine.org/carbon-monoxide-and-oxygen-transport
The presence of carbon monoxide in the blood will result in a profound decline in the capacity of blood to carry oxygen. Thus, although the partial pressure of dissolved oxygen in the blood may be normal, tissues may display severe hypoxia because much of the hemoglobin will be irreversibly bound by carbon monoxide rather than oxygen.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057251/
Apr 28, 2014 · Thus, CO leads to impaired oxygen delivery to tissues and eventually to marked tissue hypoxia when compensatory mechanisms to maintain oxygen delivery fail. However, tissue hypoxia is not the only possible explanation for the toxic effects seen.Author: Angela L Chiew, Angela L Chiew, Nicholas A Buckley, Nicholas A Buckley
https://erj.ersjournals.com/content/erj/4/10/1258.full.pdf
Tissue hypoxia occurs when cellular oxygen delivery does not fulfill cellular oxy gen demand. Cellular oxygen delivery involves a co-ordinated sequence of pulmonary oxygen transfer, convection of blood to tissue, and diffusion of oxy gen from capillary to cell.Author: R. W. Samsel, P. T. Schumacker
http://www.thedoctorwillseeyounow.com/content/public_health/art2100.html
Aug 01, 2007 · CO binding with hemoglobin interferes with the delivery of oxygen to bodily tissues. Levels of carbon monoxide in the blood can be determined by a simple blood test to measure carboxyhemoglobin. Carbon monoxide is produced naturally in …
https://www.respiratorytherapyzone.com/carbon-monoxide-poisoning-review/
CO produces tissue hypoxia by competing with oxygen for binding sites on the oxygen-carrying hemeproteins (hemoglobin, myoglobin, etc.). Carbon monoxide displaces oxygen atoms. Hemoglobin is full of carbon monoxide and is unable to deliver oxygen to the cells.
https://emcrit.org/ibcc/co/
Jan 03, 2017 · Carbon monoxide bound to erythrocytes prevents oxygen transfer to the tissues.
https://www.thoughtco.com/carbon-monoxide-373551
Carbon monoxide inhibits the blood's ability to carry oxygen to body tissues including vital organs such as the heart and brain. When CO is inhaled, it combines with the oxygen carrying hemoglobin of the blood to form carboxyhemoglobin (COHb). Once combined with the hemoglobin, that hemoglobin is no longer available for transporting oxygen.Author: Regina Bailey
https://en.wikipedia.org/wiki/CO_poisoning
The main manifestations of carbon monoxide poisoning develop in the organ systems most dependent on oxygen use, the central nervous system and the heart. The initial symptoms of acute carbon monoxide poisoning include headache, nausea, malaise, and fatigue.Other names: Carbon monoxide intoxication, carbon monoxide toxicity, carbon monoxide overdose
https://academic.oup.com/bjaed/article/16/10/341/2288629
May 17, 2016 · The taut form predominates in the tissues (a high carbon dioxide, low pH environment) promoting oxygen release, whereas the relaxed form binds oxygen more avidly in areas of high pH, low carbon dioxide tension, and high partial pressures of oxygen (such as in the alveoli).Author: J-Oc Dunn, MG Mythen, MP Grocott, MP Grocott
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