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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756404/
The elucidation of the human and mouse genome sequence and developments in high-throughput genome analysis, and in computational tools, have made it possible to profile entire cancer genomes. In parallel with these advances mouse models of cancer have evolved into a …Author: Jenny Mattison, Louise van der Weyden, Tim Hubbard, David J. Adams
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061323/
2. Nucleic Acid Delivery to the Outer Retina in the Mouse. In this section, we provide procedures for delivering nucleic acids to the outer retina of the mouse (Bennett et al., 1996; Liang et al., 2000).The surgical approach to subretinal injection depends mainly on the size of the eye.Author: Jean Bennett, Jean Bennett, Daniel C. Chung, Daniel C. Chung, Albert Maguire, Albert Maguire
https://www.nature.com/articles/s41417-018-0077-3
Jan 09, 2019 · Broekman ML, Comer LA, Hyman BT, Sena-Esteves M. Adeno-associated virus vectors serotyped with AAV8 capsid are more efficient than AAV-1 or -2 serotypes for widespread gene delivery …Author: Sherif G. Ahmed, Ahmed Abdelanabi, Mohamed Doha, Gary J. Brenner
https://www.nature.com/articles/3301043
Jan 05, 2000 · In the past few years, more than 100 clinical trials have been initiated to evaluate the potential of gene therapy to cure genetic diseases, cancer, AIDS and several other diseases in man.Author: A Jiang, R Dornburg
https://www.sciencedirect.com/science/article/pii/S0304419X09000092
2. Cancer gene discovery in the mouse 2.1. The mouse as a model for studying cancer. The mouse is a leading model system for cancer research because it has a rapid reproduction rate, breeds well in captivity, and, owing to its small size, can be maintained in large numbers in limited space. It is also genetically and physiologically similar to ...Author: Jenny Mattison, Louise van der Weyden, Tim Hubbard, David J. Adams
https://mdanderson.elsevierpure.com/en/publications/cancer-genes-from-mouse-to-man
The mouse has historically been used as the mammal of choice for genetic analyses and has served as an important model in cancer research. Gene transfer using the NHI 3T3 mouse cells have identified a number of oncogenes.Author: A. L. Børresen, R. A. Lothe
https://academic.oup.com/nar/article/43/D1/D844/2439469
Sep 04, 2014 · Queries can use mouse, human, rat, fly, zebrafish, or yeast symbols or EntrezID # and searches can be by gene, study or cancer type. This allows users to determine if a gene of interest is a putative cancer driver gene and quickly generate a list of driver genes that have been identified in a particular tumor type.Author: Kenneth L. Abbott, Erik T. Nyre, Juan Abrahante, Yen Yi Ho, Rachel Isaksson Vogel, Timothy K. Starr
https://www.pnas.org/content/pnas/116/37/18571.full.pdf
gene delivery through the cis-genetic incorporation of specific peptide motifs to the phage capsid. On direct testing, the next-generation of targeted AAVP vectors proved superior to the origi-nal prototype in vitro and in mouse models of solid tumors, by avoiding degradation in pre- …Author: Keittisak Suwan, Teerapong Yata, Sajee Waramit, Justyna M. Przystal, Charlotte A. Stoneham, Kaoutar ...
https://www.sciencedaily.com/releases/2018/04/180405150057.htm
Apr 05, 2018 · Dr. Doiron and his lab team are injecting a modified virus into the adult mouse pancreas. The virus is a delivery vehicle for two pro-cancer molecules …
https://medicalxpress.com/journals/human-gene-therapy/
Feb 12, 2020 · A new study has shown that gene therapy to treat one of the most common hereditary disorders, aldehyde dehydrogenase type 2 (ALDH2) deficiency, may prevent increased risk for esophageal cancer and ...
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