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https://www.tandfonline.com/doi/abs/10.1517/17425247.2.4.639
Aug 11, 2005 · On the delivery of small interfering RNAs into mammalian cells Mouldy Sioud The Norwegian Radium Hospital, Department of Immunology, Molecular Medicine Group, Montebello, N-0310 Oslo, Norway. [email protected]: Mouldy Sioud
https://mdanderson.elsevierpure.com/en/publications/on-the-delivery-of-small-interfering-rnas-into-mammalian-cells
title = "On the delivery of small interfering RNAs into mammalian cells", abstract = "RNA interference is becoming the technique of choice for analysing gene function and drug target validation. In this process, sequence-specific gene inhibition is initiated by small RNA duplexes, known as small interfering RNAs (siRNAs).Author: Mouldy Sioud
https://www.researchgate.net/publication/7471414_On_the_delivery_of_small_interfering_RNAs_into_mammalian_cells
However, a major obstacle to the use of small interfering RNAs (siRNAs) as therapeutics is their delivery across the plasma membrane of cells in vivo.Author: Mouldy Sioud
https://www.pnas.org/content/99/23/14943
Nov 12, 2002 · Furthermore, 21- to 23-nt dsRNAs, or small interfering RNAs (siRNAs), are capable of inducing RNAi in mammalian cells without initiating the sequence-independent dsRNA response . Consequently, the challenge to mammalian biologists has been to develop systems that deliver siRNAs efficiently into mammalian cells.Author: Gregory M. Barton, Ruslan Medzhitov
http://www.nature.com/articles/nbt1101
May 22, 2005 · Delivery of small interfering RNAs (siRNAs) into cells is a key obstacle to their therapeutic application. We designed a protamine-antibody fusion protein to deliver siRNA to HIV-infected …Author: Erwei Song, Pengcheng Zhu, Sang Kyung Lee, Dipanjan Chowdhury, Steven Kussman, Derek M Dykxhoorn, Yi...
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)31673-2
RNA interference (RNAi) is a gene silencing process induced by 21–23-nucleotide RNA duplexes called small interfering RNAs (siRNAs) and resulting in sequence-specific messenger RNA degradation post-transcriptionally in the cellular cytoplasmic region.Author: Soo In Kim, Duckhyang Shin, Tae Hyun Choi, Jong Chan Lee, Gi-Jeong Cheon, Ki-Yong Kim, Mahnhoon Park...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698461/
RNA interference (RNAi) is caused by small (21 − 23 bases long) single-stranded RNA molecules (small-interfering RNA; siRNA), which trigger silencing of target genes in a sequence-specific manner [1,2]. The siRNA's sequence is ‘anti-sense’ (or complementary) to a specific stretch of the messenger RNA (mRNA) transcribed by the target gene.Author: Saroj P Mathupala
https://www.nature.com/articles/nsmb.3050
Jun 22, 2015 · However, the precise mechanisms of small-RNA asymmetry are unclear, especially because asymmetric selection can still occur when the putative asymmetry sensors Drosophila R2D2 and mammalian Dicer ...Author: Hiroshi I Suzuki, Hiroshi I Suzuki, Akihiro Katsura, Takahiko Yasuda, Toshihide Ueno, Hiroyuki Mano,...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679364/
In recent years, the use of RNA interference (RNAi) has emerged as a powerful tool for the study of gene function in mammalian cells. The mechanism of RNAi is based on the sequence-specific degradation of host mRNA through the cytoplasmic delivery of double-stranded RNA (dsRNA) identical to the target sequence . Degradation of target gene expression is achieved through an enzymatic pathway involving the endogenous RNA-induced …Author: Chris B. Moore, Elizabeth H. Guthrie, Max Tze-Han Huang, Debra J. Taxman
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