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https://www.sciencedirect.com/science/article/pii/016836599290017L
Buccal delivery for peptide drugs ... Based on permeability considerations alone there would have been frustration enough to make research on buccal peptide delivery a low priority area. But it is because of the excellent accessibility of the absorption site, the elegance of muco-adhesive dosage forms, the prospects of high patient acceptance ...Author: Hans P. Merkle, Gregor Wolany
https://link.springer.com/article/10.1007%2Fs11095-014-1485-1
Aug 29, 2014 · With continuing advances in biotechnology and genetic engineering, there has been a dramatic increase in the availability of new biomacromolecules, such as peptides and proteins that have the potential to ameliorate the symptoms of many poorly-treated diseases. Although most of these macromolecular therapeutics exhibit high potency, their large molecular mass, susceptibility to …Author: Thiago Caon, Thiago Caon, Liang Jin, M O Claudia Simoes, Raymond Stanley Norton, Joseph Nicolazzo
https://www.researchgate.net/publication/323317941_Buccal_Delivery_of_Peptides_and_Proteins
Buccal route is a natural route and it has been used for delivery of small molecule for many years, but only during the last decade, delivery of macromolecules via buccal mucosa has attracted ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956587/
For a more thorough review on intranasal peptide delivery, see Illum et al. . The buccal route, administration of drug through the mucosal membranes lining the cheeks, is another option for peptide delivery . Drugs delivered by the buccal route are placed in the mouth between the gums and cheek .Author: Benjamin J Bruno, Geoffrey D Miller, Carol S Lim
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436075/
A review on bioadhesive buccal drug delivery systems: current status of formulation and evaluation methods. ... and aminopeptidase is the major enzymatic barrier to the buccal delivery of the peptide drugs. Aminopeptidase N and A (plasma membrane-bound peptidases) ...Author: P Chinna Reddy, Chaitanya K.S.C., Y Madhusudan Rao
https://www.researchgate.net/publication/265175817_Enhancing_the_Buccal_Mucosal_Delivery_of_Peptide_and_Protein_Therapeutics
Enhancing the Buccal Mucosal Delivery of Peptide and Protein Therapeutics. ... Buccal delivery of medication gives a convenient route of administration for both local and systemic effects ...
https://www.sciencedirect.com/science/article/abs/pii/016836599290017L
The non-parenteral delivery of peptides via mucosal routes is essential for the enlargement of the therapeutic benefit of various oligopeptides. Among…Author: Hans P. Merkle, Gregor Wolany
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