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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769877/
This buccal insulin was also studied in patients with type 2 diabetes treated with insulin, treated with oral agents, and failing diet and exercise. The outcome of these studies was positive for Oral-lyn. However, as described earlier, it is not easy to accept these data without more details.Author: Lutz Heinemann, Yves Jacques
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787057/
BUCCAL INSULIN. Buccal delivery of insulin has similar benefits as oral insulin with the advantage of bypassing GI degradation. Furthermore, the relatively large surface area results in better bioavailability. Initially, Generex Biotechnology developed Oral-lyn™ which is a liquid formulation of short acting insulin that is administered using ...
http://www.iptonline.com/articles/public/IPT_17_2005_p74_76.pdf
for the delivery of large-molecule drugs, such as insulin. Oral-lynTM is a unique oral formulation of insulin that is delivered via the RapidMistTM device directly to the mouth, where it is rapidly absorbed into the bloodstream through the buccal mucosa. Crystalline human recombinant DNA regular insulin is
https://journals.sagepub.com/doi/pdf/10.1177/193229680900300323
injections is the use of microneedles for insulin delivery. With intradermal injection or infusion of regular human insulin or a rapid-acting insulin analog, a rapid onset of action along with a meal can be achieved.2 The aim of this review is to critically review our current knowledge about oral insulin and buccal insulin, two other quite
https://www.researchgate.net/publication/278700982_The_RapidMist_System_for_Buccal_Delivery_of_Insulin
The objective of this review is to provide an update on various promising approaches that have been explored for buccal delivery of insulin. The buccal insulin spray has provided an alternative ...
https://www.sciencedirect.com/topics/medicine-and-dentistry/buccal-drug-administration
Buccal administration of insulin using a mucoadhesive drug delivery system was first performed by Nagai et al in the early 1980s. A significant hypoglycaemic response without any detectable variation in the blood glucose profile was observed for pelleted mucoadhesive polymeric nanoparticles on …
https://www.sciencedirect.com/science/article/pii/S1471489217300206
Research to achieve buccal insulin delivery is based on avoiding the GIT. • Buccal insulin clinical trials have led to variable results with no FDA approvals. • There is a rationale for buccal delivery of glucagon-like peptide 1 analogues. • Development of printed films is …Author: Javier O. Morales, Javier O. Morales, David James Brayden
https://www.researchgate.net/publication/23221165_Delivery_of_insulin_to_the_buccal_mucosa_utilizing_the_RapidMist_system
Background: Buccal delivery of insulin is still a challenging issue for the researchers due to the presence of permeability barrier (buccal mucosa) in the buccal cavity. The main objective of this ...Author: Gerald Bernstein
https://www.medscape.com/viewarticle/711237
Nov 04, 2019 · Buccal Spray of Human Insulin. Dr. Napoli and colleagues investigated the safety and efficacy of a buccal spray insulin developed by Generex, called Oral-lyn. "The device delivers the insulin to ...
https://onlinelibrary.wiley.com/doi/abs/10.1002/ddr.20131
Nov 16, 2006 · Prandial insulin is most desirable but resistance to injections limits its use. This has led to a battery of needle‐free insulin delivery systems. Buccal delivery stands out as being safe, simple, fast, flexible, and familiar to patient and physician alike.Author: Gerald Bernstein
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