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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787057/
BUCCAL INSULIN. Buccal delivery of insulin has similar benefits as oral insulin with the advantage of bypassing GI degradation. Furthermore, the relatively large surface area results in better bioavailability. Initially, Generex Biotechnology developed Oral-lyn™ which is a liquid formulation of short acting insulin that is administered using Generex's metered dosage aerosol applicator (RapidMist™).
http://www.iptonline.com/articles/public/IPT_17_2005_p74_76.pdf
The Buccal Delivery of Insulin A system for the administration of medicines directly into the mouth for absorption by the buccal mucosa is showing promise in the oral delivery of insulin – as well as other large-molecule drugs. By Gerald Bernstein at Generex Biotechnology Corporation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769877/
Buccal insulin is currently in the last stages of clinical development by one company and might become available in the United States and Europe in the coming years (it is already on the market in some other countries). The aim of this review is to critically describe the different approaches that are …Author: Lutz Heinemann, Yves Jacques
https://onlinelibrary.wiley.com/doi/abs/10.1002/ddr.20131
Nov 16, 2006 · Prandial insulin is most desirable but resistance to injections limits its use. This has led to a battery of needle‐free insulin delivery systems. Buccal delivery stands out as being safe, simple, fast, flexible, and familiar to patient and physician alike. …Author: Gerald Bernstein
https://www.medscape.com/viewarticle/711237
Nov 04, 2019 · Buccal spray delivers the insulin directly to the oropharyngeal mucosa, avoiding lung exposure, with peak action 10 minutes after administration.
https://www.researchgate.net/publication/230078371_Buccal_delivery_of_insulin_The_time_is_now
Background: Buccal delivery of insulin is still a challenging issue for the researchers due to the presence of permeability barrier (buccal mucosa) in the buccal cavity.Author: Gerald Bernstein
https://www.sciencedirect.com/topics/medicine-and-dentistry/buccal-drug-administration
Buccal delivery of insulin Bypasses the hepatic first-pass metabolism, leading to high bioavailability. Ease of accessibility of this absorption site. Low enzymatic activity. Suitable for drug excipients that mildly and reversibly irritate the mucosa. Painless administration – high acceptance by patients.
https://www.researchgate.net/publication/23221165_Delivery_of_insulin_to_the_buccal_mucosa_utilizing_the_RapidMist_system
Background: Buccal delivery of insulin is still a challenging issue for the researchers due to the presence of permeability barrier (buccal mucosa) in the buccal cavity.Author: Gerald Bernstein
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