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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC150040/
Jul 11, 2000 · The delivery of bronchodilators with metered-dose inhaler (MDI) in mechanically ventilated patients has attracted considerable interest in recent years. This is because the use of the MDI has several advantages over the nebulizer, such as reduced cost, ...Author: Dimitris Georgopoulos, Eleni Mouloudi, Eumorfia Kondili, Maria Klimathianaki
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733285/
May 30, 2019 · Biophysical model to predict lung delivery from a dual bronchodilator dry-powder inhaler. ... Lung dose was similar across inhalation flows of 30–120 L/min with a slight drop in calculated delivery at high inspiratory flows. Delivery was relatively unaffected by inhaler inclination angle. The delivered lung dose of the fixed-dose combination ...Author: Myrna B. Dolovich, Andreas Kuttler, Thomas J. Dimke, Omar S. Usmani
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/623687
Aug 11, 1997 · Conclusions: Bronchodilator delivery by means of an MDI or wet nebulizer is equivalent in the acute treatment of adults with airflow obstruction. Spacer devices were used for bronchodilator delivery with an MDI in most studies and are recommended for the treatment of acute airflow obstruction.Author: Turner Mo, Patel A, Ginsburg S, FitzGerald Jm
http://rc.rcjournal.com/content/58/9/1459
Sep 01, 2013 · Thus, timely and effective delivery of bronchodilator therapy can play an important clinical role in reducing airway obstruction, ventilatory impairment, and respiratory distress. 7–9 Studies in vitro suggest greater aerosol drug delivery during NIV than when no positive pressure is applied to a lung model. 8 Studies in children with cystic ...
https://bmjopen.bmj.com/content/9/6/e028584
Jun 01, 2019 · Prescreening bronchodilator delivery via MDI with VHC. Albuterol MDI (Ventolin, 100 µg/puff) will be shaken and primed per label before use, and the primed MDI will be inserted into a VHC. Subjects will sit upright and be instructed to place the spacer mouthpiece into the mouth with sealed lips after a maximal exhalation.Author: Jie Li, Jian Luo, Yibing Chen, Lixing Xie, James B Fink
https://journal.chestnet.org/article/S0012-3692(16)39316-3/fulltext
This double-blind crossover study compared the efficacy of two methods of delivery (MDI-spacer and nebulizer) of inhaled albuterol to patients hospitalized for an acute exacerbation of COPD. Within 24 h of admission, 20 subjects (mean age, 69 years) with severe airflow obstruction (mean FEV1, 0.69 L) were subjected to a treatment with an MDI-spacer (0.36 mg of albuterol or placebo) followed by ...Author: Richard B. Berry, Richard A. Shinto, Florence H. Wong, Judith A. Despars, Richard W. Light
http://rc.rcjournal.com/content/early/2020/01/07/respcare.07147
Jan 28, 2020 · BACKGROUND: High-flow nasal cannula (HFNC) is commonly used to provide respiratory support to pediatric patients with respiratory failure. Although the use of bronchodilators via HFNC has been described, the feasibility and safety of aerosolized bronchodilator delivery via …Author: Awni M Al-Subu, Vu T Nguyen, Yousef AlAli, Rhonda A Yngsdal-Krenz, Michael R Lasarev, Marlowe W Eldr...
https://www.webmd.com/asthma/guide/asthma_inhalers_bronchodilators
Bronchodilators are medications used to dilate the lungs’ airways, and they contain a type of drug known as a beta-antagonist. So-called rescue inhalers act in the short term, while other ...
https://ccforum.biomedcentral.com/articles/10.1186/cc698
Jul 11, 2000 · The delivery of bronchodilators with metered-dose inhaler (MDI) in mechanically ventilated patients has attracted considerable interest in recent years. This is because the use of the MDI has several advantages over the nebulizer, such as reduced cost, ease of administration, less personnel time, reliability of dosing and a lower risk of contamination. A spacer device is fundamental in order ...Author: Dimitris Georgopoulos, Eleni Mouloudi, Eumorfia Kondili, Maria Klimathianaki
https://www.atsjournals.org/doi/abs/10.1164/ajrccm.151.6.7767526
The optimal dose and technique for administration of bronchodilators with a metered-dose inhaler (MDI) in mechanically ventilated patients have not been established. We studied the efficacy and safety of 10 puffs (90 micrograms/puff) of albuterol administered by an MDI in seven mechanically ventilated patients with chronic obstructive pulmonary disease (COPD).Author: Rajiv Dhand, A. Jubran, M. J. Tobin
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