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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998643/
Many approaches to overcome, circumvent, disrupt, or manipulate the BBB to enhance delivery of drugs to brain tumors have been devised and are in active investi gation. These approaches include high-dose intravenous chemotherapy, intra-arterial drug delivery, local drug delivery via implanted polymers or catheters, BBB dis ruption, and biochemical modulation of drugs.Author: Jaishri Blakeley
https://braintumorcenter.ucsf.edu/research/drug-delivery
One area of active drug delivery research at UCSF involves the development and improvement of convection-enhanced delivery (CED), an experimental technique for directly infusing drugs into a brain tumor. With CED, a small hole is made in the patient’s skull to insert a cannula (a thin tube) that extends to the site of the tumor.
https://www.sciencedaily.com/releases/2019/12/191203102011.htm
Dec 03, 2019 · Despite improvements in drug delivery mechanisms, treating brain tumors has remained challenging. Researchers have studied the processes affecting therapeutic drug penetration into brain tumors.
https://medicalxpress.com/news/2019-12-drug-delivery-brain-tumor-treatment.html
Dec 03, 2019 · The talk, "Controlled drug delivery and release in brain tumors with focused ultrasound," was presented Monday, Dec. 2 as part of the session on cavitation nuclei. "For a …
https://www.mskcc.org/blog/drug-delivery-approach-shows-promise-treating-deadly-brain-tumor-children
Jun 15, 2018 · A lethal pediatric brain tumor called diffuse intrinsic pontine glioma (DIPG) is very difficult to treat, partly because it arises in the base of the brain and is hard to reach with drugs. A clinical trial suggests that a drug delivery technique called convection enhanced delivery (CED) is safe and effective at getting drugs to the tumor.
https://www.sciencedirect.com/science/article/pii/S2211383514000288
Brain tumor-targeted drug delivery systems, which increase drug accumulation in the tumor region and reduce toxicity in normal brain and peripheral tissue, are a promising new approach to brain tumor treatments.Author: Xiaoli Wei, Xishan Chen, Man Ying, Weiyue Lu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629063/
Apr 05, 2014 · The “systematic targeted drug delivery” or “whole-process targeting” is recognized as an effective brain tumor targeted drug delivery strategy which considers all the possible targets including barriers, microenvironment and cancer cells.Author: Xiaoli Wei, Xishan Chen, Man Ying, Weiyue Lu
https://www.nature.com/articles/s41467-019-13198-y
Nov 15, 2019 · The flexible and bifacially-designed sticky/hydrophobic device allows conformal adhesion on the brain surgery site and provides spatially-controlled and temporarily-extended drug delivery to brain...Author: Jongha Lee, Hye Rim Cho, Gi Doo Cha, Hyunseon Seo, Hyunseon Seo, Seunghyun Lee, Chul Kee Park, Jin W...
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