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https://www.sciencedirect.com/science/article/pii/S1461534700002583
May 01, 2000 · More recently, small peptide-vectors have been used to enhance brain uptake of several therapeutic drugs 16. These peptide-vectors cross cellular membranes safely and efficiently and have been used successfully to enhance penetration of several drugs. The use of drug delivery devices such as microcapsules,...Author: Jamal Temsamani, Jean-Michel Scherrmann, Anthony R Rees, Michel Kaczorek
https://www.researchgate.net/publication/223666893_Brain_drug_delivery_technologies_Novel_approaches_for_transporting_therapeutics
By passing the BBB and translocating to the blood stream, complex can facilitate certain drugs efficiency and the release of biochemical, providing novel approaches for transporting therapeutics ...
https://www.sciencedirect.com/science/article/pii/B9780323429788000048
The foremost challenge of CNS therapy is the delivery of therapeutics to target the brain with minimal effects on other tissues. First-pass metabolism of orally administered drugs and efflux pumps expressed on the BBB diminish the delivery of therapeutics to the brain [6].Author: Abhirup Mandal, Rohit Bisht, Dhananjay Pal, Ashim K. Mitra
https://drugdeliveryravneetkaur.wordpress.com/approaches-to-transport-therapeutics-across-the-bbb-to-treat-brain-diseases/
Approaches to transport therapeutic drugs across the blood–brain barrier to treat brain diseases. Neurobiology of Disease, Volume 37, Pages 47-58. Abbreviations: CNS- Central nervous system, BBB- blood brain barrier, LRP – low density lipoprotein receptor, TF- transferrin, TFR- transferrin receptor, mAb- monoclonal antibodies, CED- Convention enhanced delivery.
http://www.rroij.com/open-access/novel-approaches-for-brain-drug-delivery-systemreview.pdf
Novel Approaches for Brain Drug Delivery System-Review *Swatantra Bahadur Singh Department of Pharmaceutics, Hygia Institute of Pharmaceutical Education and Research, Ghazipur Balram Ghaila Road, Faizullaganj, Lucknow, Uttar Pradesh-226020, India.
https://www.ncbi.nlm.nih.gov/pubmed/19664710
We will mainly concentrate on the physiologic approach which takes advantage of specific receptors already expressed on the capillary endothelial cells forming the BBB and necessary for the survival of brain cells. Among all the approaches used for increasing brain delivery of therapeutics, the most accepted method is the use of the physiological approach which takes advantage of the …Author: Reinhard Gabathuler
http://www.authorstream.com/Presentation/rdafal-1353118-approaches-for-the-effective-brain-drug-delivery/
Mar 06, 2012 · Direct CNS delivery Approaches for brain drug delivery 11 Intracerebral delivery Intraventricular delivery Intrathecal delivery Intranasal delivery Intracerebral delivery: Intracerebral delivery Direct CNS delivery 12 Delivers drug directly into parenchymal space of brain Major problem with bolus inj. is slower movement of drug within the brain Large amount of dose required
https://www.giiresearch.com/report/root330379-bbb-technologies-novel-cns-drug-delivery.html
May 12, 2015 · Several companies, such as Armagen, Vect-Horus, and Angiochem, have utilized this approach to transport therapeutics into the brain. 3. These technology developers are evaluating their technologies on over 50 drug candidates spread across different development stages. 80% of these drugs are undergoing either preclinical or proof of concept and efficacy studies.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685177/
Drug delivery to the brain is hindered by the presence of the blood-brain barrier (BBB). Although the BBB restricts the passage of many substances, it is actually selectively permeable to nutrients necessary for healthy brain function. To accomplish the task of nutrient transport, the brain ...Author: Angela R. Jones, Eric V. Shusta
http://www.eurekaselect.com/157831/article
Drug based therapy requires heavy doses to cross the blood brain barrier leading to systemic toxicity. The review summarizes fifteen different patented technologies for targeting the drug substance specifically to the tumor site in the brain. Result: Targeted drug delivery strategies serve as an efficient tool for treating brain cancer.Author: Viral Shah, Pratiksha Kochar
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