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https://www.researchgate.net/publication/231222991_Brain_Drug_Delivery_Systems_for_Neurodegenerative_Disorders
Brain Drug Delivery Systems for Neurodegenerative Disorders. Neurodegenerative disorders (NDs) are rapidly increasing as population ages. However, successful treatments for NDs have so far been limited and drug delivery to the brain remains one of the major challenges to overcome.
http://www.eurekaselect.com/103508/article
Abstract: Neurodegenerative disorders (NDs) are rapidly increasing as population ages. However, successful treatments for NDs have so far been limited and drug delivery to the brain remains one of the major challenges to overcome.
https://dadun.unav.edu/bitstream/10171/34785/3/BRAIN%20DRUG%20DELIVERY%20SYSTEMSS.pdf
advances made in the field of brain drug delivery for treating neurodegenerative disorders. Examples include polymeric micro and nanoparticles, lipidic nanoparticles, pegylated liposomes, microemulsions and nanogels that have been tested in experimental models ofAuthor: E. Garbayo, E. Ansorena, M.J. Blanco-Prieto
http://europepmc.org/abstract/MED/23016644
Oct 01, 2012 · Neurodegenerative disorders (NDs) are rapidly increasing as population ages. However, successful treatments for NDs have so far been limited and drug delivery to the brain remains one of the major challenges to overcome.Author: E. Garbayo, E. Ansorena, M.J. Blanco-Prieto
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321229/
A global view of the AD pathophysiology is described in order to understand the need for an effective treatment and why nanoparticles (NPs) could be an important weapon against neurodegenerative diseases by solving the general problem of poor delivery into the central nervous system (CNS) for many drugs.Author: Cristina de la Torre, Valentín Ceña
https://www.sciencedirect.com/science/article/pii/S1773224717305981
A major hurdle for the treatment of neurodegenerative disorders is the inability of drug molecules to cross the blood-brain barrier (BBB). Many anti-Parkinson and anti-Alzheimer drugs lack brain targeting; this impedes their ability to reach maximum effective concentrations in the brain.Author: Shadab, Subrat K. Bhattmisra, Farrukh Zeeshan, Naiyer Shahzad, Ali Mujtaba, Venkata Srikanth Meka, A...
https://www.sciencedirect.com/science/article/pii/S0168365916303236
The use of nanoparticle (NP) formulations able to encapsulate molecules with therapeutic value, while targeting specific transport processes in the brain vasculature, may enhance drug transport through the BBB in neurodegenerative/ischemic disorders and target relevant regions in the brain for regenerative processes.Author: Cláudia Saraiva, Catarina Praça, Raquel Ferreira, Tiago Santos, Lino Ferreira, Liliana Bernardino
https://www.ncbi.nlm.nih.gov/pubmed/25039773
In this respect, nanosized drug carriers were shown to enhance the delivery of drugs to CNS compared to equivalent drug solution formulations. Neurological conditions that have been studied in animal models that could benefit from nose-to-brain delivery of nanotherapeutics include pain, epilepsy, neurodegenerative disease and infectious diseases.
https://www.researchgate.net/publication/279408805_Brain_targeting_Drug_Delivery_System_A_Review
In order to distribute the drugs into the CNS via passing the blood brain barrier, many new emerging approaches have been developed for example Magnetic drug targeting, chemical delivery Systems ...
https://www.eurekamagazine.co.uk/design-engineering-features/technology/drug-delivery-is-key-to-treatment/225972/
“There is currently no approved method for the chronic delivery of drugs for neurological disorders into the brain,” explains Dr Max Woolley, technical fellow and head of Drug Delivery Device Research and Development, at Renishaw. “This device has the potential to completely change how neurological diseases are treated.
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