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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392984/
May 21, 2013 · To obtain insight into the properties of drug delivery vehicles that direct their intracellular processing in brain endothelial cells, the intracellular traffic of fixed-size nanoparticles in an in vitro BBB model as a function of distinct nanoparticle surface modifications has been investigated.Author: Massimo Masserini
https://www.sciencedirect.com/science/article/pii/S0168365916303236
Nanoparticles (NPs) are considered one of the most auspicious and versatile drug delivery systems into inaccessible regions like the brain, being able to provide protection to therapeutic agents while efficiently delivering them into the damaged areas.Author: Cláudia Saraiva, Catarina Praça, Raquel Ferreira, Tiago Santos, Lino Ferreira, Liliana Bernardino
https://www.hindawi.com/journals/isrn/2013/238428/
As a consequence, several strategies are currently being sought after to enhance the delivery of drugs across the BBB. Within this review, the recently born strategy of brain drug delivery based on the use of nanoparticles, multifunctional drug delivery systems with …Author: Massimo Masserini
https://medicine.yale.edu/neurosurgery/news-article/23744/
3 days ago · The nanoparticles have wider implications than drug delivery. They can be stimulated to emit a fluorescence, which helps surgeons locate tumor to remove with greater accuracy. Still, there’s a long road ahead before this research can be applied in a clinical setting, says Dr. Zhou.
https://drdavidchangmd.com/how-nanoparticles-could-shape-the-future-of-brain-cancer-treatment/
Apr 09, 2020 · The nanoparticle therapy has been successful in trials involving mice, and while there are still plenty of hurdles to clear before it could be seen as a reliable drug delivery option for humans, there is hope on the horizon for patients with malignant brain tumors.
https://newatlas.com/medical/nanoparticles-blood-brain-barrier-cancer/
3 days ago · “But this finding suggests a new direction for developing nanoparticles for drug delivery to the brain by targeting LAT1 molecules.” The research was published in the journal Nature Biomedical ...
https://www.researchgate.net/publication/258390711_Nanoparticles_for_Brain_Drug_Delivery
W ithin th is review, the recently born strategy of brain drug delivery based on the use of nanoparticles, multifunctional drug delivery systems wi t h size in the o rder of on e-billionth o f ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527668/
Physical association of the drug to the nanoparticles was necessary for drug delivery to occur into the brain (Kreuter et al 2003). When nanoparticles with different surface characteristics were evaluated, neutral nanoparticles and low concentrations of anionic nanoparticles were found to have no effect on BBB integrity, whereas high concentrations of anionic nanoparticles and cationic nanoparticles …Author: Wim H De Jong, Paul Ja Borm
https://www.sciencedirect.com/science/article/pii/S2211383516301186
6.1. Potential neurotoxicity of the NPs CNS is highly protected from exposure to xenobiotics and toxic substances by the BBB66. The brain targeting delivery system is a double-edged sword because it improves the drug concentration in diseased cells of brain as well as the drug and NPs exposure to normal brain…Author: Huile Gao
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