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https://www.sciencedaily.com/releases/2019/09/190924101450.htm
Sep 24, 2019 · The blood-brain barrier (BBB) regulates the delivery of all substances from the blood circulation into the brain. Its main function is to protect the central nervous system (CNS) from harmful...
http://jpet.aspetjournals.org/content/370/3/593
Sep 01, 2019 · Although the BBB limits the delivery of certain drugs to the brain and, as such, hampers the treatment of certain CNS disorders, accessing the brain via the nose-to-brain route has been demonstrated by scores of preclinical studies and about a dozen clinical trial results.Author: Zian Wang, Guojun Xiong, Wai Chun Tsang, Andreas G. Schätzlein, Ijeoma F. Uchegbu
https://www.pharmatutor.org/articles/direct-nose-to-brain-delivery-drugs-nanoparticulate-approach-review
Delivery of drugs to the brain is a major challenge due to presence of physiological barriers that restricts the delivery of drugs to CNS. Thus, since last few decades, nasal route has been attracted a wide attention of researchers as a convenient, reliable, and safe, being non-invasive, route to achieve faster and higher levels of drug absorption in the brain.
https://www.ncbi.nlm.nih.gov/pubmed/28966266
Intranasal administration appears to be an ideal solution for drug delivery to the brain, bypassing the BBB, however the entry of peptide drugs into neuronal …Author: 亀井 敬泰
https://pubs.rsc.org/en/content/articlelanding/2019/nr/c9nr02876e
While new brain tumor cell-specific drugs are continuously becoming available, efficient drug delivery to brain tumors remains a limiting factor. We developed a multicomponent nanoparticle, consisting of an iron oxide core and a mesoporous silica shell that can effectively deliver drugs across the blood–brain barrier into glioma cells.Author: O. Turan, P. Bielecki, V. Perera, M. Lorkowski, G. Covarrubias, K. Tong, A. Yun, A. Rahmy, T. Ouyang...
https://www.sciencedirect.com/science/article/pii/S0169409X11002900
Thus, this enhanced endocytosis activity associated with diseased brain supports the rationale for designing drug delivery systems with cationic proteins or peptides (e.g. cell-penetrating peptides) as a means to maximise the drug transport into the diseased brain.Author: Yan Chen, Lihong Liu
https://drug-dev.com/nasal-delivery-a-promising-route-of-drug-delivery-to-the-brain-scientific-considerations-2/
NASAL DELIVERY – A Promising Route of Drug Delivery to the Brain: Scientific Considerations ABSTRACT One of the factors that limit the ability of most of the drugs to treat Central Nervous System (CNS) disorders is related to the extent of drug that is able to cross the Blood Brain Barrier (BBB).
https://www.slideshare.net/VARSHAAWASAR/brain-targeted-drug-delivery-system
Aug 04, 2014 · INTRODUCTION • Drug delivery to the brain is the process of passing therapeutically active molecules across the Blood Brain Barrier for the purpose of treating brain maladies. This is a complex process that must take into account the complex anatomy of the brain as well as the restrictions imposed by the special junctions of the Blood Brain Barrier.[3] •
https://www.nibib.nih.gov/science-education/science-topics/drug-delivery-systems-getting-drugs-their-targets-controlled-manner
Delivering drugs into the brain is critical to the successful treatment of certain diseases such as brain tumors, Alzheimer’s disease, and Parkinson’s disease, but …
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