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https://www.researchgate.net/publication/282739296_Biphasic_Drug_Delivery_In_Controlled_Release_Formulations_-_A_Review
Biphasic drug delivery system is an innovative drug delivery system for oral administration which is composed of one fast release layer and one sustain release layer. Layered tablet concept is utilized to develop controlled and sustained release formulations.
http://ijpsr.com/bft-article/biphasic-oral-solid-drug-delivery-system-a-review/?view=fulltext
INTRODUCTION: Biphasic delivery systems are designed to release a drug at 2 different rates or in 2 different periods of time: they are either quick/slow or slow/quick. A quick/slow release system provides an initial burst of drug release followed by a constant rate (ideally) of release over a …
http://www.ijpsi.org/Papers/Vol5(7)/E0507022030.pdf
Formulation and evaluation of oral biphasic drug delivery system of Metronidazole using HPMC .. Weight variation test was done by weighing 20 tablets individually and collectively, calculating the average weight from the collective weight and comparing …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227916/
Mitoxantrone, an antineoplastic agent, was chosen as a model drug due to its ability to interact ionically with alginate and exhibit delayed release. [31] Cumulative mitoxantrone release from biphasic ferrogels increased with decreased iron oxide content, a potential advantage for in vivo applications ( Figure 5A ).Author: Christine A. Cezar, Christine A. Cezar, Stephen M. Kennedy, Stephen M. Kennedy, Manav Mehta, Manav M...
https://www.drugdiscoverytrends.com/dermal-delivery-of-large-molecule-drugs/
Apr 11, 2013 · Using biphasic vesicles Delivery of drugs through the skin includes two classes that are associated with distinct purposes. Dermal delivery. Dermal delivery involves delivery of a drug into the skin itself for dermatological treatments, vaccinations, or cosmetic applications. Transdermal delivery. Transdermal delivery also uses the skin as the application site, but introduces the drug for transport …
https://www.mdpi.com/2073-4360/11/2/369/htm
In order to achieve prolonged drug delivery, poly(lactic- co -glycolic acid) (PLGA) has been widely studied to form microneedles [ 16, 17, 18, 19, 20 ]. For some drugs or vaccines, however, biphasic release would be more desirable to maximize therapeutic efficiency and reduce administration frequency.Author: Seok Chan Park, Min Jung Kim, Seung-Ki Baek, Jung-Hwan Park, Seong-O Choi
https://www.sciencedirect.com/science/article/pii/S0378517302005781
Jan 16, 2003 · A modification of these systems can produce biphasic drug delivery where drug release is controlled in the upper GIT while release is accelerated in the colonic region by degradative action of pectinolytic enzymes resident in the colon.Author: Kwabena Ofori-Kwakye, John T Fell
https://www.mdpi.com/2073-4360/11/2/369/pdf
The concept of layered microneedles for biphasic drug delivery. Once inserted, the microneedle would be embedded in the skin due to dissolution of water-soluble polymers, and rapidly release drugs incorporated in a water-soluble matrix.Author: Seok Chan Park, Min Jung Kim, Seung-Ki Baek, Jung-Hwan Park, Seong-O Choi
https://www.sciencedirect.com/science/article/pii/S037851730200546X
Hydrophilic materials may therefore act as drug release regulators in mixed film coatings. By altering the leaching characteristics of films, biphasic drug delivery, where some of the dose in a dosage form is released in the upper GIT, and the remainder in the colon, may be achieved.Author: Kwabena Ofori-Kwakye, John T Fell
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