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https://www.researchgate.net/publication/282739296_Biphasic_Drug_Delivery_In_Controlled_Release_Formulations_-_A_Review
Biphasic drug delivery system is an innovative drug delivery system for oral administration which is composed of one fast release layer and one sustain release layer.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419157/
Feb 20, 2019 · (A) Schematic diagram of spray deposition setup for polymer microneedle fabrication. (B) The concept of layered microneedles for biphasic drug delivery.Once inserted, the microneedle would be embedded in the skin due to dissolution of water-soluble polymers, and rapidly release drugs incorporated in a water-soluble matrix.Author: Seok Chan Park, Min Jung Kim, Seung-Ki Baek, Jung-Hwan Park, Seong-O Choi
http://ijpsr.com/bft-article/biphasic-oral-solid-drug-delivery-system-a-review/?view=fulltext
INTRODUCTION: Biphasic delivery systems are designed to release a drug at 2 different rates or in 2 different periods of time: they are either quick/slow or slow/quick.A quick/slow release system provides an initial burst of drug release followed by a constant rate (ideally) of release over a defined period of time.
https://www.researchgate.net/publication/49843497_Biphasic_Vesicles_A_Novel_Topical_Drug_Delivery_System
This paper reviews the application of a novel topical delivery system, biphasic vesicles built from nanoscale components, to the delivery of several therapeutic agents and vaccine antigens and ...
https://www.mdpi.com/2073-4360/11/2/369/htm
The blank PLGA layer acted as a diffusion barrier, resulting in a reduced initial burst. The formation of the PLGA diffusion barrier was visualized using confocal microscopy. Our results suggest that the spray-formed multilayer microneedles could be an attractive transdermal drug delivery system that is capable of modulating a drug release profile.Author: Seok Chan Park, Min Jung Kim, Seung-Ki Baek, Jung-Hwan Park, Seong-O Choi
http://www.ijpsi.org/Papers/Vol5(7)/E0507022030.pdf
Formulation and evaluation of oral biphasic drug delivery system of Metronidazole using HPMC .. www.ijpsi.org 23 P a g e HPMC polymer to retard the release of the drug[7]. HPMC retardation of drug release occurs by swelling of the matrices upon the exposure to the gastric fluids.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628262/
A biphasic gastroretentive floating drug delivery system with multiple-unit mini-tablets based on gas formation technique was developed to maintain constant plasma level of a drug concentration within the therapeutic window.Author: Meka Lingam, Thadisetty Ashok, Vobalaboina Venkateswarlu, Yamsani Madhusudan Rao
https://www.scholarsresearchlibrary.com/articles/formulation-and-evaluation-of-capincap-technology-for-biphasic-drug-delivery-of-glimepiride.pdf
Biphasic delivery systems are designed to release a drug at two different rates or in two different periods of time: they are either quick/slow or slow/quick[2,3]. Capsule-in-Capsule Drug Delivery System Capsule in Capsule - The dual capsule system available to the pharmaceutical industry which can facilitate theAuthor: Pritee S. Mahajan, S. B. Gondkar, R. B. Saudagar
https://www.mdpi.com/2073-4360/11/2/369/pdf
transdermal drug delivery system that is capable of modulating a drug release proļ¬le. Keywords: layered microneedles; heterogeneous composition; biphasic release; rapid drug release; sustained drug release; spray deposition 1. Introduction Microneedles are designed to deliver pharmaceutical compounds across the skin in a minimallyAuthor: Seok Chan Park, Min Jung Kim, Seung-Ki Baek, Jung-Hwan Park, Seong-O Choi
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